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Cholesterol: Fact vs. Fiction

Learn how to prepare yourself against this silent killer

Every cell in your body contains cholesterol. You can’t live without it. But, everyone also knows its central role in developing heart disease. So, how can you best prepare yourself against this silent killer? Vigilance.

Have your cholesterol checked. And, understand how cholesterol works, recommends Cleveland Clinic heart surgeon Marc Gillinov, MD, and cardiologist Steven Nissen, MD. Can you tell fact from fiction?

1. Diet is the most important factor in determining your cholesterol level.

False. Eighty percent of the body’s cholesterol is made by the liver. That means, only 20 percent comes from your diet. That’s why it is so hard to lower cholesterol through diet alone. By banning nearly all cholesterol from your diet, you might be able to reduce your total cholesterol level by about 20 percent.

Understanding this can often make the choice to take cholesterol-lowering drugs easier. If you need to reduce your cholesterol by 50 percent, you cannot accomplish this through diet alone. You’ll need a good diet and the right medication.

2. Total cholesterol is more important than LDL (bad cholesterol) alone.

False. Although attention was paid to total cholesterol in years past, today the focus is on LDL. Your LDL level is the best predictor of your risk of heart attack and stroke. Simply put, lower is better. For example, if you have two 55-year-old men, the one with an LDL of 125 has a higher risk of developing heart disease than the one with an LDL of 90 – even though both of their LDL levels are in the normal range.

So, what should your LDL be? If you have coronary heart disease, your LDL cholesterol should be 70 mg/dL or less. If you have major risk factors for coronary artery disease, your LDL should be 100 mg/dL or less. A LDL of greater than 130 mg/dL is unhealthy even if you don’t have heart disease.

3.  No cholesterol pill can cancel out the effects of a Big Mac.

True.  British cardiologists proposed a tongue-in-cheek solution to our infatuation with fast food. Why not take a statin with your burger, fries and milkshake? No cholesterol-lowering pill can make up for a steady diet of Big Macs and other foods filled with excess calories and saturated fats. The authors suggest, “Better ways to reduce your risk of disease from heart attack include: eating healthily, exercising, maintaining a healthy weight, and not smoking.” We wholeheartedly agree.

Marc Gillinov, MD, heart surgeon and Steven Nissen, MD, cardiologist and chair of Cardiovascular Medicine are authors of the new book Heart 411.

Update 1/20/2012

Thank you all for taking the time to comment on this article. Our mission at the Cleveland Clinic is to provide people with information that is both accurate and guided by research. It sounds as though some of you have had success with improving your lipid profile with a plant based diet. For others, this is not the case.

It is important to  remember  that all patients are not created equal, and we recommend that you work with a preventive cardiology team (including doctors, nurses, exercise specialists and dietitians) that can evaluate your lipids and risk profile and work with you to create a plan to help you reach your goals. Optimizing your lipid profile requires a heart-healthy diet (low in saturated fat and cholesterol and rich in vegetables and fiber) and exercise. The extent of dietary changes one wants to make is individualized. People with a very high LDL cholesterol will usually require a combination of medications and dietary measures. When patients do choose to follow a strict and very limited diet, we encourage  them to see a dietitian to make sure you are not missing out on important nutrients needed by  the  body.

Last,  some comments suggested taking vitamins, supplements and herbals. Please speak to your doctor first before taking any of these.   Supplements may be costly and may not provide any benefit. In addition, some supplements can interact with medications and cause harm. Our Preventive Cardiology Clinic staff is always available to work with you either by appointment or e-consultation.

Good luck to all of you in your efforts to be heart-healthy!

Tags: cholesterol, heart 411, heart and vascular institute, heart health, prevention, risk factors
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  • Dan Kinnaird

    I have been on the Atkins diet since 2002 and I eat a lot of fat and protein, but few carbs. Since that time, my LDL has been 90 or less. It was always higher prior to 2002. What is the exact effect that the carbs have on converting fats to cholesterol. I know that the caloric intake is large with the fats and protein that I eat but I can’t understand the decrease in cholesterol and my total trigycerides have remained around 55 during the entire time.

    • CCHeart

      I have asked our Preventive Cardiology Nutritionist your question and will have an answer for you end of week. betsyRN

  • Carolyn Thomas

    It seems this post tends to gloss over the “right medication” advice. I’d be interested in Drs Gillinov and Nissen’s take on recent research findings that suggest cholesterol-lowering statin drugs are NOT effective for primary prevention of cardiovascular disease (despite all those industry-funded studies which claim they are). For example, cardiologist Dr. Roger Blumenthal at Johns Hopkins told the American Heart Association’s 2010 Scientific Sessions meeting in Chicago:

    “Statin therapy should NOT be approached like diet and exercise as a broadly based solution for preventing coronary heart disease. These are lifelong medications with potential side effects.”

    This may be especially true for women, both for those with and without diagnosed heart disease.

    • CC Heart

      Dear Carolyn, I forwarded your comment to Dr. Nissen and Dr. Gillinov, coauthors of Heart 411. They stated, “Statins are not for everyone, but it is simply incorrect to state that they are not effective in primary prevention. Several large studies have demonstrated a reduction in heart attack and stroke when appropriate patients with elevated cholesterol (and other risk factors) are treated. We should always recommend a heart healthy diet and regular exercise, as we do in Heart411, but diet and exercise alone are not enough for many patients. Statins work equally well in men and women”.

  • Alice Coker

    I am a 79 year old female who takes no medication and has total cholesterol running 220 to 240 with a ratio of 3 to 3.4, homocystine and cardio crp levels normal or below. I have supplemented with Shaklee products for 25 years and my doctor tells me I am the only patient she has who gets better with age. Last year I added Virgin Coconut Oil to my diet and my cholesterol is down to 202 still with high HDL and low ratio as well as other factors. Lifeline screening shows no abnormal plaque buildup. Why can’t the medical community stop pushing drugs and push for good health. My friends who think their doctors are saving them cannot keep up with me. They drag, they complain about their pain, their energy but they love their doctors who are promoting getting old by means of drugs. I love that I can still work a full day and enjoy an evening out. Drug free. What a life, how fortunate I am that someone introduced me to the Shaklee way of living 25 years ago instead of taking drugs for RA as was prescribed. Granted I do not eat Big Mac and I do eat for my health, but that is easy and very tasty.

    • CC Heart

      Dear Alice – Very impressive results. I forwarded your note to Dr. Hazen – and he said Congratulations! betsyRN

    • Beth

      Right on Alice! I did the same with my step-mom. When she came to live with me she was on high blood pressure med, a statin for her cholesterol, anti-depressants plus oral meds for diabetes! I said hey, let’s see if we can stop this crazy train and did nothing other than switch her to the whole foods diet we eat, rich in eggs, butter and cheese, pastured beef, wild caught salmon and moose, coconut oil, Real salt (mined in Redmond, Utah), lots of (primarily) organic vegetables (including plenty of fermented veggies and beverages) and bone broths. I switched her regular coffee to decaf and removed wheat and diet sodas from her diet (except for the occasional loaf of sourdough). She takes supplemental Vit D3, iodine, calcium and magnesium. The only med she’s on is a minimal dose of natural thyroid.
      My doctor (integrated family medicine) explained the medical world’s love affair with statins and especially the statistics they use to support their love. Her cardiologist still thinks they are a good thing but he can’t explain away the statistics: the people who actually benefit from statins are a VERY small percentage of the populace. The side effects are worth researching too.
      Keep on keeping on Alice… but don’t expect a radical change in the mainstream standard of care. Teach those whose minds are open to learn.

  • Tom Calarco

    Why wasn’t HDL levels mentioned? Doesn’t it play a role in offsetting LDL? So far as diet, won’t a vegan diet significantly lower cholesterol, and doesn’t food you eat have a role in how much cholesterol your liver produces?

  • Dee

    Several doctor friends from Pittsburgh told me that a high HDL number permits a higher cholesterol number. Is that so? And what would the ratio be? My HDL is 89. How high can my cholesterol be and still be considered acceptable? Would appreciate your view.

  • evan wise

    How does sugar, carbohydrates, fiber, and other nutrients affect LDL? Exercise as a means to lower LDL?

  • Joe

    Cholesterol hype by the medical industry is a big profitable lie. The NNT value for antibiotics is 1.1, meaning for every 11 persons taking an antibiotic 10 will benefit. The NNT value for statins to lower cholesterol is 100 – for every 100 persons taking a statin only 1 will benefit. If lowering cholesterol is so great, how come 99 out of 100 people still suffer just as much as those who don’t take a statin. Because cholesterol is not the cause of clogged arteries.

    • CC Heart

      Dr. Nissen replied, “It is not appropriate to compare antibiotics to statins. Antibiotics can cure infectious diseases. Statins don’t cure high levels of cholesterol, they reduce them. Depending on the population studied, the number needed to treat for statins can be as low as 25, for example, in a patient with a high cholesterol after a heart attack. Also please consider the types of events we can prevent with statins. Antibiotics may “cure” an earache in a child, but statin reduce the risk of heart attack, stroke, and death. The evidence that cholesterol is involved in “clogging” of arteries is so well established that virtually every medical expert agrees. Many of us are not beholden to pharmaceutical companies, but we do want the best for our patients. Given to the right patients, statins can reduce the incidence of a devastating disease.”

  • CC Heart

    I sent these comments to Dr. Nissen and Dr. Gillinov, coauthors of Heart 411. They stated, “HDL levels are important, but the evidence is somewhat less strong for a benefit from high HDL than evidence for increased risk from a high LDL. The Vegan diet is not necessarily healthy. We recommend a Mediterranean diet that contains low amounts of saturated fats, lots of fruits and vegetables, and reasonable amounts of healthy fats from oils like olive or canola oil. A HDL of 89 is considered very healthy, but we always look at the totality of information. Someone who smokes, has a strong Family history, and untreated high blood pressure may have elevated risk despite a high HDL.

    Sugar and carbohydrates tend to increase triglycerides, but have little effect on LDL. Fiber slightly lowers LDL. Exercise may slightly lower LDL and raise HDL.”

  • Bea Sterling

    All this tells me is that five different cardiac doctors in a room will disagree on what’s best for heart patients. Some doctors say no oil, others say “good” oils, etc. Doctors can’t even agree on how long to keep someone on Plavix, or to put them on Plavix, etc. (based on talking to other heart patients). I complained for about 10 days with jaw pain while my tests kept coming back ok. So my heart doc of 10 years said it was my high BP (which I wasn’t having until the jaw pain).
    A week later, an MI/bypass surgery followed and surprise, surprise, I had severe heart disease and several blockages. AFTER being on 80 mg Pravachol and under a cardiac docs care for 10 years. We know our own bodies better than the doctor, it just takes forever to get the doctor (sometimes) to listen to us. A lot of women/men put on anxiety meds really do have heart problems. Anybody ever feel like you have to scream to get someone’s attention that you really do have a serious problem? I’m scared to get off the Pravachol and scared to stay on it!

  • steve

    I had a heart attack back in August 2011. (3 stents) At the time my hdl was at 39 and my ldl was at 103. I researched diets and decided to become a vegan with no oils. My bloodwork in december showed my hdl at 29 and ldl at 40 overall cholesterol at 106. How can i improve my hdl ? I’m taking 500 mg of niacin and 10 mg of lipator daily. I’m 42 years young and now weigh about 165lbs. Thanks for any help.

    • CCHeart

      I asked Dr. Hazen, Section Head of Preventive Cardiology your question. He stated: “Raising HDL is difficult.
      At present, our data suggests that when LDL is below treatment goal (< 70 for you), chasing after raising HDL may not provide added benefit (at least with current medications). When LDL is as low as 40, recent studies indicate we perhaps dont have to worry as much about a very low HDL as we used to....
      So I recommend keep doing what you are doing from lipid standpoint.
      There are other ways to lower CVD risks, like regular exercise program, monitoring blood pressure and salt intake, smoking cessation, etc. antiplatelet therapy, being on an ACE inhibitor or ARB, and a beta blocker are also recommended for someone with multivessle disease.
      We would be happy to see you in preventive cardiology clinic to see if there are any other adjustments beyond the lipid levels that are recommended”.

  • fran

    Another big secret about statin drugs is that it causes memory loss. Ones memory is who you are and I would rather have a heart attack then loss my memory. I see it in my family right now where this person is losing her memory at such a fast rate and has been on statin drugs for a long time.

  • Lee Schelin

    The whole cholesterol myth has been perpetrated by the Pharmaceutical companies. I’ll be 71 in February. and my lifelong cholesterol level has never exceeded 150 yet I’ve had two heart attacks in the past 20 years. The latest research I’ve read indicates that inflammation causes plaque build up, not Cholesterol. After the last heart attack in 2007 the doctors put me on a statin and it damned near killed me….never again

    So why do most of the doctors continue to state that cholesterol is the problem? Those that do have lost my confidence in them

  • jerry

    When I found my cholesterol caused a blockage and I went on Lipitor, I did everything right as far as diet….no french fries, eggs, bacon or sausage, potato chips, and everything was terrible my next blood work…..so I said what the heck, went back to my normal diet, and the next blood work was great….so go figure ?? Just take the pill and hope for the best in my case !!

  • Joe
    • Beth

      No Joe, you are correct in your math. That is what my family doctor explained to me. They put out a statistic to make it look like it’s a really effective med but they don’t explain the fine print: that it’s really effective in only a minute number of people. That is, only a percentage of a very small number can expect it to help them.
      Now they’ve got their bead on the next market share they hope to capture: kids. Yep, kids on statins. Follow the money.
      Who pays for those new, top of the line facilities in medical school? Pharmaceutical companies. Follow the money and you will find that Pharm leads the way in the medical world.

  • http://yahoo Bob Dixon

    I am 63 years old. 240 lbs,6’4″. In 1999 I was put on low dose statins when my total cholesterol was 180 and the the good was only mid 30′s. Since then and for the last 11 years my total cholesterol is only 115 to 125,my triglyceride is only about 48,my HDL around 55 and my LDL around 50. I don’t exercise except for drinking 3 or 4 glases of wine with diner,I eat a cheese burger almost daily,etc. I pass all my stress tests, and I go to your hospital yearly for a heart check up. My primary care DR. says it’s the statins which are keeping me heart healthy.

  • http://whitfieldproperties.com Steve Whitfield

    I’ve just started reading this newsletter as a result of my recent trip to CC to get a valve repair, which subsequently was not performed because it wasn’t as bad as was originally thought. The heart cath did reveal a little coronary heart disease in my pulmanary artery(25% blockage) and suddenly my “acceptable range” 130 cholesterol is too high and my family doctor put me on Lipitor. I’m 63 yrs. young and in charge of a thriving business and this person fran tells me that memory loss is the big “secret ” re: statins. Come on people,you’re opening up a world to me that is starting to scare me a little. Who’s on first?

  • http://ClevelandClinic Stephen A. Otto, ED.S.

    I had a coronary calcium test done in April of 2010, with a total Agatston score of 285.70. The left anterior descending artery comprised 225.70 of this total score. Do you agree that an Agatston score between 100-400 is consistent with a 1.3% annual risk of a heart attack or death from coronary heart disease over a 2 to 5 year period in my case? With my numbers (the other 3 artery numbers were 27,28 and 5) should this test be repeated in certain yearly intervals? Your thoughts and recommendations please.

    • CC Heart

      Dear Stephen – Dr. Nissen replied, “We don’t recommend use of the calcium test in most patients and never advise patients to have the test repeated. The “normal” amount of calcium in the coronaries depends on your age, so a score of 285 is more abnormal if you are young vs. older. The test exposes patients to significant amounts of radiation, which has its own hazards. The best advice is to manage your controllable risk factors, including cholesterol, blood pressure, diabetes and smoking cessation. Again, I strongly advise NOT to repeat this test.” betsyRN

  • Daryle

    Please help me understand some things. I am a 59 year old women who has a cholesterol level of 242, HDL 49 and LDL 185. My BP is 106/62, I have never smoked and I don’t drink alcohol. I walk 3-4 miles per day about 4-5 times per week and play golf (walk) during the summer months. My doctor and friends say I should be on statin drugs but other doctors tell me that statin drugs do not work on women as well as with do for men. I just saw a program on television where an internist say the drugs to avoid are statins and BP meds for low blood pressure. I passed my stress test last year, the one that takes the picture of the heart after running on the treadmill. Plus my calcium score was zero. Are there any other tests that I should have before I take a medication that I possible don’t need. My mother is still alive at 94 and I my father died at 85 of a cerebral hemmorgage, he had a major heart attack at age 62 never took any statin drugs and ate bacon and eggs most mornings. I feel as though this is all guess work and no one really knows the answers. Most doctors agree that medicine is 50 % knowledge and 50% guessing. Please let me know about other test that are available.

    • CC Heart

      Daryle – Dr. Cho, Director of our Women’s Cardiovascular Center stated that statins work in women just as well as they do in men. Some studies say that women may have side effects – you will want to work with your doctor on managing your levels. Primary prevention data is just as strong for women as men. You may want to see a Preventive Cardiology Clinic who specializes in working with patients on diet, exercise, and medications to optimize their heart health. If you like – you can come to Cleveland Clinic’s Women’s Cardiovascular Center, a part of Preventive Cardiology. There are other studies you can take such as us-CRP and others to better define your risk. betsyRN

  • http://www.seriousstrength.com Fredrick Hahn

    Great article Marc!

    You said:

    “Every cell in your body contains cholesterol. You can’t live without it. But, everyone also knows its central role in developing heart disease. So, how can you best prepare yourself against this silent killer?”

    Aye there’s the rub. We are all doomed. You can’t live with it and can’t live without it. What are we to do?

    But wait – here’s a thought that I think is completely original! What if LDL cholesterol in general is being wrongly accused? I know it’s a totally stupid and wacky idea. But what if we DO have it all wrong? What if it isn’t LDL cholesterol per se that is “bad,” but instead, the production of too much of a certain type of lipoprotein (namely small, dense LDL particles) caused by chronically elevated blood glucose levels caused by eating too much total carbohydrate? Crazy right? Ah, why bother thinking about this I guess. I mean, we already KNOW what it is right?

    Still, it sure is too bad no one in history has ever thought about or written about this hypothesis. Maybe someday someone with the proper medical credentials will. A great title for a future book like this would be: The Great Cholesterol Con or The Cholesterol Myths.

    But in the meantime, just take your statins like your doctor says even though you don’t currently have CHD or CVD or other cardiac risk factors -just high cholesterol (high because who said so?) – you know that stuff that virtually every cell in your body can make and is essential to life itself.

    It’s certainly worth, as I see it, to destroy your nervous system little by little, expose yourself to tendon ruptures, risk sudden cardiac death and liver failure just in case.

    After all, if a doctor tells you to do something it has to be right, right?

  • Fredrick Hahn

    Steve -

    Get off your vegan diet ASAP! Eat plenty of saturated fats from grass-fed meats, fatty fish and non-starchy veggies. Eat no grains or processed foods. You’ll be better in no time. The idea that eating fat and cholesterol causes heart disease is not and never was true.

    • Bob Dixon

      I posted above you. I do not eat any thing with wheat,rye,barley or oats also. When I eat at the “Golden Arches or Wendy’s ,which is daily,I tell them no bun please”. I think if you combine the grains with the fat ,something happens! My statin is Vytorin 10/20., not Lipitor.GO VYTORIN!

  • Chris

    How do you know if you have coronary artery disease if you have not had a heart attack? My cholesterol is is 243, Ldl 146, hdl 85, triglycerides 54. I had chest pain about 1 month ago for 2 hours while eating. Had a stress test (with no injection) and echocardiogram. Stress test fine. Echo showed a sclerotic valve, moderate regurg at tricuspid, mild regurg at mitral. Been having pressure in upper sternal region and in throat. Ultrasound of thyroid showed 3 solid nodules and “global thyroid disease”. I don’t know what global thyroid disease means but can you tell from lab results if I have coronary artery disease? Could heart be causing symptoms if stress test is okay? Or, do you think its a thyroid problem? What kind of follow-up would you suggest? My sister had a heart attack at age 59 & I am 56. Dad died of MI at 67. Thank you.

  • Nancy

    What is lowest safe level of Triglycerides? I was taking 6 grams a day of Lavaza (fish oil). This level was prescribed due to studies that said higher levels were showing value in decreasing depression. I have been on 4 grams daily for 3 years. Suddenly, after 2 months of being on the 6 grams, my Triglycerides dropped to 19. (Average for me in many previous years had been 50+/-. After dropping back to 5 grams daily, testing results was 39. I’m 61 and never had high triglycerides but have sporadic atrial fib well controlled by medication. I can find a lot of info on what is too high a level, but what is too low and what is ideal?

    • CC Heart

      Dear Nancy – I spoke to Dr. Hazen, Section Head of Preventive Cardiology. He stated “There is no known lower limit level for Triglycerides. “

  • thad

    i have been taking statins for five days now and when i wake up in the morning, feel like i am sinking in my chair. they make me feel weak and listless. what are the warning signs for someone to get off them?

    • CC Heart

      You should call your doctor regarding yoru symptoms. These symptoms may or may not have been caused by your medications. You can learn more about statins or your specific medication at the National Library of Medicine MedLine Plus – http://www.nlm.nih.gov/medlineplus/statins.html

  • Daryle

    What are the other test you talk about besides the CRP? The last line of your answer to me.
    Daryle

  • Jen

    It is so discouraging to see the way question number one was answered. Several years ago, I REDUCED MY CHOLESTEROL OVER 100 POINTS IN 4 MOS WITH DIET ALONE.
    Yes, livers make cholesterol. It goes into our digestive tract as liver bile, where it is re-absorbed through the intestines into our bloodstream. Once it’s back in the bloodstream, it’s available to wreck havoc on arteries. Here’s the diet trick: If you eat a minimum of 12 grams of soluble fiber a day, spread throughout breakfast, lunch and dinner, the soluble fiber binds with the liver bile and prevents the cholesterol from being re-absorbed into the bloodstream. However, for this diet trick to be effective, people also need to improve what they eat, and eliminate meat and dairy fats and partially-hydrogenated oils from their diet, and increase their omega-3 intake.
    There is an excellent book written by Robert Kowalsky called The 8-week Cholesterol Cure that outlines this information. I found it in the library after I refused my doctor’s statin prescription and tried a diet approach first. My brother is on statins, has excruciating muscle pains, and uses the answer to number one in this newsletter as an excuse not to change his diet. Sadly, I’m waiting for him to have his second heart attack (the first came at 50) and don’t think he’ll have a second chance again.
    After trying a diet approach, I gradually went back to my old eating habits, and my cholesterol creeped up again. I’ve since changed to a plant-strong diet (Nutritarian, thanks to Dr. Joel Furhman), and become familiar with Dr. Esselstyn’s advice, and his son, Rip’s recipes. Fortunately, I found all this info before I needed a cardiologist or a cardiac surgeon.

  • CC Heart

    So many comments, we had to update the article! Thanks for taking the time to write! betsyRN

  • Daniel

    Funny, how all those rural chinese peasants who habitually follow a “not necessarily healthy” plant based/whole food diet (see: THE CHINA STUDY) never seem to have heart disease (or cancer, for that matter). A real marketing nightmare for big pharma, though there IS light at the end of the tunnel. As China becomes more prosperous, they will soon adopt our lifestyle (and diseases). With billions of new customers coming on line, stocks of the drug manufacturers that make statins should be a sound investment!

  • Nancy RN

    yes and its better to have patients so sick they cant move without pain from the statins and increased confusion mentally i guess its like who cares if your in pain we can order you another pill for that..If your confused its ok at least you wont have a heart attack…its all the pharm $$$$$

    • The_Beating_Edge_Team

      As noted above, not all patients are created equal. Patients need to work with their health care team on healthy lifestyle efforts such as diet and exercise. When that does not lower LDL to decrease their risk for heart disease, they will need to work with their doctor to find the right medicine to help them. Those that have severe muscle pain or other side effects should not take the medicine. By working with a skilled Preventive Cardiology team – definitely with the patient at the center of the team – usually the right combination can be found. betsyRN