How Soon Should Immunocompromised People Get the COVID Booster Shot?

While the news is promising, check with your healthcare provider first
immunocompromised getting booster shot

Q: With the FDA authorizing third doses of the COVID vaccines for the most vulnerable, how soon can someone who is immunocompromised schedule an appointment?

A: On August 12, 2021, the FDA updated its emergency use authorization for both Pfizer-BioNTech’s and Moderna’s COVID-19 vaccines for immunocompromised individuals, specifically, solid organ transplant recipients (kidney, liver, intestines, heart, lung and pancreas) or those who are diagnosed with conditions considered to be at the same level of immunocompromise.

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Transplant recipients have to be very careful because their immune systems are suppressed to reduce the chances of their bodies rejecting the new organs they receive. Overall, immunocompromised people are at increased risk for poor outcomes from COVID-19, and studies have shown a reduced antibody response for this patient population after vaccination.

In July, the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) presented “Data and Clinical Considerations For Additional Doses In Immunocompromised People” during a meeting. One finding in this presentation was that recent studies have indicated that additional COVID-19 vaccine doses in immunocompromised people enhanced antibody responses and increased the proportion that responded. In smaller studies, the immunological responses of the third dose were about the same as prior doses.

Currently, the CDC recommends that moderately to severely immunocompromised people receive an additional dose. This includes people who have:

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  • Received active cancer treatment for tumors or cancers of the blood.
  • Received an organ transplant and take medicine to suppress their immune system.
  • Received a stem cell transplant within the last 2 years or take medicine to suppress their immune system.
  • Moderate or severe primary immunodeficiency (such as DiGeorge syndrome or Wiskott-Aldrich syndrome).
  • Advanced or untreated HIV infection.
  • Active treatment with high-dose corticosteroids or other drugs that may suppress your immune response.

If you qualify, you can get the third dose of a COVID vaccine as soon as possible. However, talk to your healthcare provider first to determine if you should.

— Hematologist Matt Kalaycio, MD

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