September 27, 2019

Your Mood May Affect How Well Your Mind Functions

Understanding the link between the two

Older woman depressed and forgetful comforted by daughter

If you suffer from depression, there’s a good chance your mental sharpness is diminished along with your mood.


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When that happens, you might fear that Alzheimer’s disease or another form of dementia has begun. The symptoms of depression may be mistaken for signs of dementia, but they also might be an indicator of cognitive impairment, especially if the depression begins late in life.

For all these reasons, if you have mood and/or memory troubles, seek an evaluation to determine the cause and find out if treating depression can counter any cognitive problems you might be experiencing.

“We know that depression takes away your cognitive crispness and efficiency,” says psychiatrist Leo Pozuelo, MD.

Many times, somebody may be referred because they have what’s believed to be dementia, but it turns out they have depression. You treat the depression, and they recover their cognitive skills.

“Vice versa, people who have established dementia are at higher risk of having depression,” Dr. Pozuelo explains. “That’s why it’s always important to screen for depression in people who are having cognitive problems.”

What’s the link between depression + dementia?

Depression may affect more than your mood. The mood disorder has been associated with increased inflammation, which studies suggest may play a role in dementia as well as cardiovascular disease. Also, if you feel down, you might be less likely to adhere to a healthy lifestyle and more prone to engage in unhealthy behaviors, such as binge eating/following a poor diet, remaining sedentary, smoking and consuming alcohol in excess — all of which may affect your brain health and cognition.

Several studies have implicated depression and anxiety as potential risk factors for dementia later in life. For example, researchers reported that among more than 1,100 older adults, depression was associated with a reduction in brain size and increases in memory problems and markers of brain aging. In other research, scientists analyzing data from 34 studies (involving a total of 71,244 dementia-free participants) found that depression was significantly associated with a decline in cognitive function.


What symptoms do depression and dementia have in common?

Depression and dementia share symptoms, which can make it difficult to distinguish between the two conditions:

  • Concentration difficulties.
  • Problems with executive function (such as decision making, planning, paying attention to detail and problem solving).
  • Reduced mental processing speed.
  • Loss of interest in pleasurable activities.
  • Social withdrawal/isolation.
  • Increased irritability.

Compounding the situation is that both disorders can occur at the same time, and depression may make existing cognitive impairment worse, explains geriatric medicine specialist Ronan Factora, MD.

“There’s this interplay between depression and cognitive impairment,” he says. “I treat the depression because I expect there to be improvement. Some folks will have their cognition normalize, so it’s all due to depression. Others have cognitive impairment that persists even when the mood symptoms go away.”

“Sometimes you might not get an idea about the cognitive deficit of a person until you treat the depression,” Dr. Pozuelo adds. “Then, once you treat the depression, you have a much clearer picture about whether there’s an underlying cognitive disorder to treat.”

Seek help for your depression

The only way to find out for sure what’s causing your cognitive troubles is to seek an evaluation from a healthcare professional. The physician can diagnose depression using a simple questionnaire, and they can then decide if further cognitive testing is necessary.

If your cognitive complaints are due primarily to depression, treatment with psychotherapy and, if necessary, medications may restore your cognitive function along with your mood.


Addressing your depression may offer some benefit even if you already have some cognitive decline. In one study, researchers reported that in patients with mild cognitive impairment and a history of depression, treatment with antidepressants known as selective serotonin reuptake inhibitors (SSRIs) for more than four years delayed the progression to Alzheimer’s dementia by about three years compared with shorter-term SSRI treatment, use of other antidepressants or no treatment.

“If you feel depressed, bring it up with your doctor to see if something else is going on, particularly if it’s new,” Dr. Factora advises.

“In folks who are older, the common thing to do is to say it’s just due to aging, but that makes you ignore treatable conditions, and depression is very treatable.”

What you can do to protect your mood + brain

  1. Adhere to a heart- and brain-healthy diet rich in fruits, vegetables and whole grains and low in saturated fat, added sugars and sodium.
  2. Get at least 30 to 45 minutes of moderate-intensity exercise a day. Physical activity is a known mood booster and may promote better overall brain and cognitive health.
  3. Stay intellectually and socially engaged. Take part in mentally stimulating activities you enjoy, and seek opportunities to interact with family and friends.
  4. Ask your physician if your cognitive problems may be due to depression or other secondary causes, such as sleep disorders (like obstructive sleep apnea and insomnia), testosterone or B12 deficiency, thyroid dysfunction (such as hypothyroidism), medications (especially if you take more than one), vision or hearing problems, alcohol abuse.

This article originally appeared in Cleveland Clinic Men’s Health Advisor.

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