Locations:
Search IconSearch

Are Weight-Loss Pills Right for You?

These meds may help you kick-start your weight-loss plan

Tape measure and weight loss pills

Experience is generally a good thing, but not when it comes to dieting. Knowing the ins-and-outs of every diet plan probably means you’ve tried them all … and maybe ended up right back where you started. An “E-for-effort” doesn’t count, unfortunately, when you’re trying to lose weight to improve your health.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Endocrinologist and obesity specialist Marcio Griebeler, MD, explains how prescription weight loss medications may help you be done with dieting for good.

Q: Who can use weight-loss medications?

A: Prescription weight-loss medicines can help people kick-start weight loss as a means of improving overall health. They are currently available for people who meet specific criteria:

  • A body mass index (BMI) of 30 or more: We consider someone with a BMI of 30 or more to have obesity.
  • A BMI of 27, plus one or more associated conditions: These weight-related problems include diabetes, high blood pressure, high cholesterol or joint pain.

Q: How do prescription diet pills work?

A: In most people, weight loss medicines work on the brain to curb your appetite. Initially, this can jump-start weight loss. Over time, however, your body adjusts, and the medication may be less effective.

At that point, you may need to increase the dosage to get the same effect. In some states, like Ohio, laws limit how long you can use the medications. In general, weight-loss pills aren’t intended for long-term use.

Q: So can I pop a pill and watch my waistline shrink?

A: Sorry, but no. A weight-management physician may recommend prescription weight-loss medicines as part of a package that includes:

  • Nutrition: Eating the right amount of high-quality foods, including fruits, vegetables, whole grains and lean proteins.
  • Exercise: Increasing movement, even a little bit, helps to spur weight loss. As you begin to lose weight, you’ll be able to exercise more often and for longer.
  • Stress management: Stress can impact how your body functions and may cause you to eat more.
  • Quality sleep: Poor sleep can cause you to feel fatigued, which can impact your desire to exercise and eat well. It can also slow down your metabolism.

Advertisement

Q: What are the risks of weight-loss pills?

A: As with any medication, there are risks, most often in the form of side effects. Plus, some of the medicines are controlled substances — while it’s unlikely you’ll become addicted, we monitor you closely so you don’t develop a dependency.

Side effects associated with prescription weight loss pills include:

  • Dry mouth.
  • Fatigue .
  • Headache.
  • Increased heart rate.
  • Kidney stones.
  • Increased blood pressure .

Q: What results will I get from prescription weight-loss pills?

A: The average weight loss is between 6 and 15% of your body weight within six to twelve months. Losing just 5% of body weight can make a big difference when it comes to conditions like diabetes, cholesterol and high blood pressure. Right now, there are around six medicines on the market, so if one option doesn’t work for someone, we can often try something else.

Q: How often will I need to see a doctor?

A: Once you’ve learned the risks and benefits and have decided to pursue medication, we usually recommend a six-month commitment to start. Patients should be seen at least monthly. In Ohio, because of prescription laws, you must have a monthly appointment. You might also see a dietitian and behavior health specialist for added support.

Our goal is to help you adopt habits that will serve you lifelong. When you go off medicines, you may regain the weight. But with healthy lifestyle changes, you’ll have a higher chance of keeping the weight off for good.

Advertisement

Learn more about our editorial process.

Related Articles

Mason jar of pureed vegetables with broccoli, carrots and potatoes around it
March 28, 2025/Weight Loss
Can the Baby Food Diet Help You Lose Weight?

It can, but it isn’t sustainable, lacks nutritional balance and you’ll likely regain weight as soon as you start eating adult foods again

Woman eating a salad at her kitchen counter
March 18, 2025/Nutrition
Can Time-Restricted Eating Help You Lose Weight?

Consuming all of your calories in an eight- to 12-hour timeframe may help you drop pounds

Person holding smartphone, looking at diet app
March 10, 2025/Weight Loss
How the Cleveland Clinic Diet App Works

No one diet is right for everyone — but the Cleveland Clinic Diet app meets your personalized needs

Person sitting at table eating from a plate full of food, thinking about other foods and meals floating around their head
December 9, 2024/Nutrition
What Is Food Noise? And How To Quiet It

Constantly thinking about food can make it hard to maintain a healthy weight and can lead to other health issues

Person doing squats on mat at home
September 4, 2024/Weight Loss
This Is How To Lose Weight the Right Way — and Keep It Off

Successful weight loss takes a long-term commitment to healthy living — create a healthy lifestyle you can keep up

Person with overweight sitting on couch looking at phone
July 26, 2024/Weight Loss
7 Possible Reasons Why Your Weight Fluctuates

Hormones, water retention and even exercise can play a part in daily weight changes

Person standing on a scale in bathroom, with over-sized 30-day calendar floating
July 15, 2024/Weight Loss
Why Losing 10 Pounds in a Month Isn’t the Right Goal

Rapid weight loss isn’t sustainable or healthy — for weight loss success, focus on long-term solutions

Juiced fruits and veggies dispensing from a juicer on counter in kitchen
April 24, 2024/Weight Loss
What You Need To Know About Juicing for Weight Loss

Juicing cleanses don’t target fat loss — and you’ll lose important nutrients in the process

Trending Topics

Person in bed sleeping on their side, covers off
Breathing Problems? Try These Sleep Positions

If you’re feeling short of breath, sleep can be tough — propping yourself up or sleeping on your side may help

A couple looking at skyline, with one person slightly behind the other, head bent down
What Is Anxious Attachment Style — and Do You Have It?

If you fear the unknown or find yourself needing reassurance often, you may identify with this attachment style

Glasses and bottle of yellow-colored prebiotic soda, with mint, lemon and ginger garnish
Are Prebiotic Sodas Good for You?

If you’re looking to boost your gut health, it’s better to get fiber from whole foods

Ad