Search IconSearch
January 18, 2021/Living Healthy/Wellness

Why You Shouldn’t Mix Energy Drinks and Alcohol

Mega-doses of caffeine mixed with alcohol may be dangerous

empty cans of energy drinks and alcohol

If you’re planning on partying any time soon, you might be planning what sort of drinks to have. And one popular choice over the last several years has been to mix alcohol with caffeinated energy drinks.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

While this may seem like a good idea – the energy drink overpowering alcohol’s drowsiness effects – there are some negative side effects that warrant consideration.

Registered Dietitian Julia Zumpano, RD, warns the high caffeine content in energy drinks may get you to drink more than your limit. “Caffeine is a stimulant but once you come down from that high you want it again, just like coffee,” she says. “It’s a very addictive effect.”

We chatted with Zumpano to get the low-down on why you should avoid such a troubling mix, no matter what your situation is.

The alcoholic energy drink craze

In the late 2000s, brands flooded the market with canned beverages that packaged the two ingredients together, resulting in a wave of popularity for drinks like Four Loko and Sparks. But, in 2010, the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC) sent warnings to several companies that produced these drinks.

According to the FTC, these drinks presented a risk to consumer health because, “Consumers – particularly young, inexperienced drinkers – may not realize how much alcohol they have consumed because caffeine can mask the sense of intoxication.”

Several drinks, like Four Loko, altered their drinks by dropping caffeine from their ingredients list. Other brands simply pulled their lines altogether.

Even with those specific drinks pulled from the market, though, the chance to mix energy drinks with alcohol remains an easy enough cocktail to make. Drinkers just have to make their own mix instead of relying on these pre-mixed formulas. And with that remains certain dangers.


Caffeine’s effect on intoxication

According to Zumpano, researchers have spent a lot of time over the years exploring the way in which energy drinks might reduce the sensation of intoxication — which may induce more drinking.

Researchers not only wanted to find out if energy drinks offset the sedating effects of alcohol, but they were also looking to determine if the reduced sensation of intoxication impairs judgment relative to risky behaviors, like drunk driving or binge drinking.

“Alcohol has this sedative effect. It makes you feel more relaxed” says Zumpano. “But it also has the residual effect of making you feel tired. Some people like being relaxed but not feeling tired so they add caffeine, a stimulant, to bring them back up, to enjoy the feeling of being relaxed without feeling tired.”

The problem, she says, is that the stimulation can mask how drunk you actually are, prompting you to overdrink. Additionally, she points out that because of the caffeine intake, you’ll have more energy through the night meaning you might be drinking longer and taking in more alcohol.

That syncs with the conclusions of multiple studies in the decade since that initial wave of popularity: yes, mixing alcohol with energy drinks does seem to increase the desire to consume more alcohol and could result in more alcohol-related injuries.

As for whether or not these drinks alter one’s perception of how intoxicated they are, the evidence has been less conclusive so far.

Issues with the heart

Another side-effect of consuming energy drinks is potential damage to the heart. As Zumpano notes, both caffeine and alcohol have their own separate effects on blood pressure and, when combined, can create even more havoc.


One 2018 study tested 44 non-smoking, healthy students in their 20s, exploring the impact one 24-ounce energy drink had on the function of their blood vessels. According to the study, “vessel dilation was on average 5.1% in diameter before the energy drink and fell to 2.8% diameter after, suggesting acute impairment in vascular function.”

And a 2016 study found that while acute energy drink consumption didn’t lead to a significant increase in heart rate, it did lead to a significant increase in both systolic and diastolic blood pressure. This is particularly bad for someone who already has elevated blood pressure, Zumpano says, but it can also lead to long-term problems if you don’t.

Given that it’s already been established that excessive amounts of alcohol can negatively impact your heart health, combining it with energy drinks could up that risk even more. “If you’re consistently drinking and combining caffeine and alcohol, forcing your blood pressure to be elevated, you’re increasing your risk of stroke, heart attack and heart disease,” she says. “And long term excessive alcohol use can negatively affect your kidneys and your liver, too.”

Caffeine and alcohol both stimulate atrial fibrillation (irregular heartbeat), Zumpano adds, noting that people who already suffer from it should be even more cautious when consuming alcohol, caffeine or both combined.

There’s also a question of sodium. “Some caffeinated/energy drinks could contain sodium which could further increase your blood pressure,” Zumpano adds.

And this is all further compounded by the way both alcohol and highly caffeinated drinks can drastically alter your sleep pattern which can lead to even more heart issues.

Loaded with calories

Besides all of these other issues, Zumpano says sugar-laden energy drinks will definitely put a big dent in your diet. And that, in turn, can still circle around to have a big negative impact on your heart health.


“Alcoholic drinks can range from 100 calories up to 500 calories per drink, depending on what you’re having. A traditional 9oz pina colada provides 500 calories and 63 grams of sugars,” she says.

And it’s not just mixed drinks; Zumpano points out that stout beers brewed with coffee, which have become increasingly popular over the years, carry plenty of calories and caffeine, too.

Beyond the caloric content of the alcohol, most of these energy drinks average between 250 to 300 calories, says Zumpano, so they add up very quickly. “If you have three of those drinks, now you’ve got a 900-calorie intake from those alone. If weight loss or weight management is a goal for you, that intake is going to adversely affect your goals.”

There’s also the issue of sugar, which is a common, loaded ingredient of the energy and caffeinated drinks. “High amounts of alcohol and simple sugars lead to elevated blood triglycerides,” she adds. “Triglycerides are fats in the blood that are separate from cholesterol but can still contribute to plaque formation in the arteries.”

That kind of consumption can lead to fatty liver disease or pancreatitis. Additionally, the alcohol-caffeine combo can also lead to elevated blood sugar and blood triglyceride levels which can lead to a higher risk of diabetes.

How to mitigate risks

Zumpano says the best way to make sure you don’t risk these health issues is simply to avoid mixing caffeine with alcohol, particularly when that includes energy drinks.

“If you do want to have alcohol but want to stay up later, try having a separate caffeine drink a few hours before,” she suggests. “And try avoiding high levels of caffeine. Instead of an energy drink, try a caffeinated tea, a small cup of coffee or a shot of espresso.”

If you do like mixed drinks, Zumpano recommends using a club soda, flavored water or seltzer as a mixer. She also suggests avoiding high sugar drinks. Besides the issue of sugar, people are more inclined to consume more sweet drinks and have them quicker which could lead to over-consuming.

Finally, she suggests including water between each alcoholic and/or caffeinated drink. Water will help you rehydrate, which can lessen the effects of a hangover the next day. Water between each alcoholic drink will also help you consume less alcohol, calories and sugar.


Learn more about our editorial process.

Related Articles

Female breast feeding baby
Can You Drink Alcohol While Breastfeeding?

An occasional drink is OK, and you can safely nurse your baby after the alcohol has left your breast milk

Glass of celery juice with stalk garnish
May 16, 2024/Weight Loss
Celery Juice Is a Trendy Detox Drink, but Does It Actually Have Benefits?

While it isn’t bad for you, celery juice isn’t the detox phenom it’s claimed to be

Juiced fruits and veggies dispensing from a juicer on counter in kitchen
April 24, 2024/Weight Loss
What You Need To Know About Juicing for Weight Loss

Juicing cleanses don’t target fat loss — and you’ll lose important nutrients in the process

Male holding pill and glass of water, with assorted alcohol behind him crossed out
April 22, 2024/Primary Care
Why You Should Avoid Alcohol on Antibiotics

Even a little alcohol can slow your recovery, so it’s best to wait until after you finish your antibiotics before imbibing

Spoonful of apple cider vinegar
March 27, 2024/Weight Loss
Does Apple Cider Vinegar Help You Lose Weight?

The science on ACV isn’t very promising for weight loss or appetite suppression

Female and male waking up with hangovers in aftermath of a party
March 13, 2024/Digestive
Hangover Pills Aren’t Worth the Hype

Misleading claims, lack of scientific evidence and the risk of over-doing it are all concerns

Couple enjoying mixed drinks during the day in a bar
March 1, 2024/Wellness
Here’s Why Day Drinking Feels Different

Drinking during the day can result in drinking more than usual and worsen your sleep cycle

blurred person looking out window in background with glass of wine and bottle in foreground
February 21, 2024/Brain & Nervous System
How Does Alcohol Affect Your Brain?

Even one drink can have an impact on your cognitive function leading to slurred speech, blurred vision and impaired memory

Trending Topics

Female and friend jogging outside
How To Increase Your Metabolism for Weight Loss

Focus on your body’s metabolic set point by eating healthy foods, making exercise a part of your routine and reducing stress

stovetop with stainless steel cookware and glassware
5 Ways Forever Chemicals (PFAS) May Affect Your Health

PFAS chemicals may make life easier — but they aren’t always so easy on the human body

jar of rice water and brush, with rice scattered around table
Could Rice Water Be the Secret To Healthier Hair?

While there’s little risk in trying this hair care treatment, there isn’t much science to back up the claims