February 26, 2024/Heart Health

What It Means if You Have ‘Sticky’ Cholesterol

LDL cholesterol and lipoprotein (a) cholesterol are more likely to stick to your arteries and lead to dangerous heart events

Cholesterol blocking blood flow in artery

You’ve probably heard about the dangers of high cholesterol. But what you may not know is that cholesterol isn’t just one thing. “Cholesterol” is actually an umbrella term for a few different lipids (fats) in your blood.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

And some of those lipids are more dangerous than others.

“The type of cholesterol that we get concerned about are the cholesterol molecules that can ‘stick’ to the inside of the arteries and cause plaque formation,” clarifies cardiologist Ashish Sarraju, MD.

What kinds of cholesterol are sticky? And what can you do about it? Dr. Sarraju shares what you need to know about sticky cholesterol.

What is sticky cholesterol?

Sticky cholesterol isn’t an actual medical term. But it’s a fitting way to help explain the way that some types of cholesterol pose a risk to your well-being.

“When people talk about sticky cholesterol, they’re really talking about the LDL cholesterol particles that contribute to plaque buildup and adverse heart outcomes,” Dr. Sarraju explains.

Let’s break that down a bit.

In healthy ranges, cholesterol does an important job of keeping your body healthy by carrying fats through your bloodstream. But too much of certain kinds of cholesterol gums up the works.

There are two main kinds of cholesterol:

  1. High-density lipoprotein (HDL) cholesterol is the kind that’s considered more helpful to your body. It’s associated with less plaque formation in your arteries. Some people call HDL “good” cholesterol, as in, not sticky. (Worth noting, though, that this term is simplistic and doesn’t capture the full picture).
  2. Low-density lipoprotein (LDL) cholesterol is the kind that people — and their healthcare providers — tend to worry about. That’s because high levels of LDL cholesterol can stick to your arteries and can cause heart disease. LDL is what some people call sticky cholesterol.

And there’s one type of particle that’s similar to LDL cholesterol that’s notoriously sticky. It’s called lipoprotein (a), or Lp (a) for short.

“The subset of cholesterol particles that we really want to try to control and reduce are the ones that cause plaque and blockages,” Dr. Sarraju emphasizes. “Reducing those can reduce the risk of heart attacks, strokes and death. LDL cholesterol and Lp (a) are the sticky cholesterol we want to keep in a healthy range.”

How sticky cholesterol affects your heart

As your blood travels through your arteries, it carries HDL, LDL and Lp (a) cholesterol molecules through your body.


HDL cholesterol travels along without a problem. But if you have high levels of LDL cholesterol or Lp (a) molecules, they may as well be coated in super glue.

As they bump up against your artery walls, they grab hold and don’t let go, hanging around inside your artery walls. That’s called arterial plaque.

More blood, carrying more LDL cholesterol and Lp (a) molecules, comes by. They also glue themselves to your artery walls and the plaques. Over the years, those plaques become bigger and bigger as more sticky cholesterol is deposited. That can lead to atherosclerosis, a condition where your arteries become harder and narrower due to plaque formation.

As time goes by, it gets harder for blood to get through the narrowed arteries. And it takes a big toll on your body.

“Plaque buildup can cause a host of adverse outcomes,” Dr. Sarraju warns.

For example:

  • Plaque buildup in the arteries of your heart can lead to heart attacks.
  • It can lead to angina, which is a blockage that’s big enough to block blood flow.
  • You can have chest pain or shortness of breath, which can affect your quality of life and prevent you from exercising.
  • Plaque buildup in the arteries that supply your brain can put you at risk for stroke.
  • Buildup in the arteries of your leg can cause peripheral artery disease (PAD), which causes pain, limits walking and can threaten the blood flow to your feet or toes.

How do you know if you have high levels of sticky cholesterol?

Dr. Sarraju reminds us that high cholesterol often doesn’t cause symptoms.

“High cholesterol and high blood pressure — these are silent killers,” he cautions. “You only know if you’re at risk for plaque formation if you get your lipid levels checked. Or if, unfortunately, it’s found after a major medical event, like a heart attack.”

Keeping up with regular screenings with a healthcare provider is the best way to keep tabs on your cholesterol.

Lipid screenings are a pretty routine part of a regular physical exam. And while those blood tests can share insight into your HDL and LDL cholesterol numbers, they don’t typically test for Lp (a). If you or your provider are concerned about your risk for Lp (a), further blood tests will be needed.

Even slightly elevated cholesterol levels should be addressed, Dr. Sarraju encourages. “Research has shown us that exposure to cholesterol is cumulative. The longer you’re exposed to heightened cholesterol levels, the more you’re at risk for plaque formation. And plaques typically don’t go away once they form.”


How to manage sticky cholesterol

Your cholesterol levels are a matter of both your genetics and your lifestyle.

“There is a genetic component to how much cholesterol your body makes,” Dr. Sarraju says. “Lp (a) is especially known to be inherited.”

A genetic component, yes. But your family history isn’t a destiny.

Choices you make can also help keep your cholesterol at a healthy level. That includes things like:

But even with these steps, your healthcare provider may prescribe medications to keep your cholesterol at a healthy level.

“We want people to do their best with a healthy lifestyle as a fundamental step because it will help your body stay healthy in so many ways,” Dr. Sarraju affirms.

“If LDL cholesterol doesn't significantly change with lifestyle changes, taking medication isn’t a personal failing. It’s just that in your case, we need to take additional steps, possibly because of genetics. But maintaining healthy habits is important — no matter your genetics and no matter if you’re taking medication.”

Sticky cholesterol isn’t always something you can manage on your own. But with a healthy lifestyle and close cooperation with your healthcare provider, you don’t have to get stuck with high cholesterol.

Learn more about our editorial process.

Related Articles

Person enjoying container of assorted fruit
February 28, 2024/Heart Health
How To Protect Your Heart When You Have Prediabetes

You can counter the risk of prediabetes-related heart attack or stroke by eating more fruits, vegetables and whole grains, as well as exercising regularly

Doctor shaking hands with patient, with large heart and EKG line behind them
February 19, 2024/Heart Health
How Weight Affects Your Heart

Having underweight, having overweight and having obesity can be dangerous for your heart

Close up of hands holding heart rate wearable watch monitor and their phone
February 12, 2024/Exercise & Fitness
Next Time You Exercise, Consider Wearing a Heart Rate Monitor

This technology can benefit your workouts by helping you hit your target heart rate, resulting in better overall health and wellness

seated doctor and female in doctor office, with female's hand on heart, with daughter
February 8, 2024/Heart Health
Here’s When You Should Go to the Hospital for a Dangerous Heart Rate

A resting heart rate below 35–40 beats per minute or over 100 beats per minute may be cause for concern

healthcare provider speaking with older female in office
February 6, 2024/Women's Health
How Estrogen Supports Heart Health

Your natural estrogen levels support a healthy heart by improving your cholesterol, increasing blood flow and reducing free radicals

Flaxseed sprinkled on a salad in a white bowl on a dark wooden table
January 31, 2024/Nutrition
Flaxseed: A Little Seed With Big Health Benefits

Ground flaxseed is full of heart-healthy omega-3s, antioxidants and fiber, and easy to add to just about any recipe

Older male in doctor's office with doctor holding tablet showing heart statistics
January 31, 2024/Heart Health
Extra Heartbeats: Should You Be Worried?

They’re rarely cause for concern, but you should still talk to a healthcare provider about your symptoms

person in wheelchair lifting weights in gym
December 26, 2023/Heart Health
7 New Year’s Resolutions To Improve Your Heart Health

Resolve to move a little more, drink a little less, eat a little healthier, sleep a little better and destress a lot

Trending Topics

Person in yellow tshirt and blue jeans relaxing on green couch in living room reading texts on their phone.
Here’s How Many Calories You Naturally Burn in a Day

Your metabolism may torch 1,300 to 2,000 calories daily with no activity

woman snacking on raisins and nuts
52 Foods High In Iron

Pump up your iron intake with foods like tuna, tofu and turkey