Locations:
Search IconSearch

What Is Magic Mouthwash?

What you need to know if your doctor prescribes a topical mouthwash

woman using mouthwash in bathroom

Magic mouthwash is a prescription-only topical treatment with the power to ward off mouth sores. But is it a bona fide treatment or sleight of hand? Internal medicine doctor Janet Morgan, MD, unlocks the secrets behind the magic.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Prescription mouthwashes conjure relief

“Magic mouthwash, sometimes called miracle mouthwash, comes in different formulas,” says Dr. Morgan. “Patients pour some medicated liquid in their mouth, then swish and spit, like they would with normal mouthwash.”

Magic mouthwash is formulated to address mouth sores that could result from:

  • Cancer treatment: Chemotherapy or radiation therapy can affect the cells in the mouth, leading to sores or blisters.
  • Oral thrush: If you took a potent antibiotic that wiped out good bacteria, you might develop an overgrowth of yeast that looks like small white bumps on the tongue and palate.
  • Viral infection: Many viruses can cause cold or mouth sores, such as the herpes virus and hand, foot and mouth disease (common in young children). HIV can also make you more prone to mouth sores.
  • Bacterial infection: The bacteria known as streptococcus infects the throat and tonsils, causing pain.
  • Autoimmune diseases: When the body’s immune system attacks its tissues or organs, sores and changes in saliva may occur.
  • Behcet’s disease: This rare disorder causes an inflammation of blood vessels in the mouth, leading to sores.

What’s the secret sauce in magic mouthwash?

Dr. Morgan says every formula is different and depends on the person’s specific needs. Magic mouthwash may contain one or more of these ingredients:

Advertisement

  • An antibiotic to kill bacteria.
  • Antifungal medicine to get yeast back in balance.
  • Lidocaine or other numbing medicine to soothe the pain from mouth sores.
  • Steroids or antihistamines to reduce inflammation.
  • An antacid to coat the mouth and offer relief.

“Sometimes, the mouthwash can be the treatment,” says Dr. Morgan. “But we use it more often to temporarily relieve pain or swelling while we wait for other treatments to resolve the underlying problem.”

Mouthwash is topical, which means it targets just the affected area rather than the entire body. Dr. Morgan says it’s a great alternative to an ingestible medicine that could interact with other drugs a person might be taking for an illness: “Whenever possible, we prefer to start with a topical option.”

How do you use a prescription mouthwash?

“Generally, a person uses the mouthwash four times a day for about a week,” says Dr. Morgan. “You put a teaspoon or two in your mouth then swish it around to coat all the surfaces before spitting it in the sink.”

Dr. Morgan’s other tips for magic mouthwash success:

  • Don’t fret if you swallow some — since the dose is small, accidentally swallowing it once or twice won’t harm you.
  • Try to avoid eating or drinking for 30 minutes after using the mouthwash to give it time to work.
  • Solutions with lidocaine numb your mouth and throat, so avoid hot beverages that could burn you without you realizing it.
  • Refrigerating the mouthwash will make the experience more pleasant, but it won’t make a big difference if you keep it out. Just shake it well before using.
  • Mouthwash will probably last for at least 12 months unless the bottle says otherwise.
  • Sharing is not caring. Don’t share the mouthwash among family members, since the formulas differ. Even if two family members both have strep throat, talk with your provider before sharing a mouthwash.

Advertisement

Learn more about our editorial process.

Related Articles

Person holding black-bristle toothbrush and jar or oil
October 23, 2025/Oral Health
Is Oil Pulling Good for You?

This oral health practice doesn’t have proven benefits, and it’s not a substitute for brushing and flossing

Healthcare provider holding clipboard, talking to patient sitting on exam table
July 15, 2025/Primary Care
Cold Sore? Here’s How To Get Rid of It Fast

Prescription oral antivirals are your best bet, but OTC creams can help, too

Person putting gum in their mouth
May 1, 2025/Oral Health
10 Tips To Relieve Your Dry Mouth

Stay hydrated, use a humidifier and try sugar-free candies or over-the-counter products with xylitol

Person pulling bottom lip down to show mouth ulcer
May 28, 2024/Oral Health
Is It a Canker Sore or Cancer? Look for These Signs

Non-cancerous ulcers usually heal within a few days or weeks — if it’s sticking around, it’s time to get it checked

Cold sore on bottom lip
November 10, 2023/Primary Care
Common Cold Sore Triggers, Explained

Lots of things can activate the herpes simplex virus, from the common cold and cold weather to cracked skin and cosmetic procedures

Person drinking glass of ice water through straw.
October 19, 2023/Oral Health
What To Do When You Burn the Roof of Your Mouth

Get quick relief with ice chips, popsicles, milk and saltwater

zoom in on lips with cold sore
June 14, 2023/Skin Care & Beauty
Cold Sore vs. Lip Pimple: What’s the Difference?

Clogged or inflamed pores cause one; a contagious virus causes the other

Person brushing teeth while looking in mirror in bathroom.
October 20, 2022/Oral Health
How Your Oral Health Affects Your Overall Health

Your teeth and gums have a huge role to play in other, more systemic health conditions

Trending Topics

woman applying moisturizer after shower
The Best Winter Skin Care Tips

How to deal with itchy, red or flaky dry skin

Glasses of alcohol on wooden stump outside in the snow, with bottle nearby
Drinking Alcohol in the Cold? 5 Tips on How To Stay Safe

A cold one out in the cold can cause a false sense of warmth and increase your risk of hypothermia

Ad