Locations:
Search IconSearch
February 6, 2020/Health Conditions/Allergies

Allergy Tests: Now You Can Find Out if You’re Allergic to a Male or Female Dog

An advanced blood test is changing the allergy game

Woman allergic to dog being held by man

Dog allergies are pretty common. People who have allergic reactions to dogs are usually reacting to the pet’s dander, which is made up of secreted proteins from dead skins cells, saliva or urine. (Yuck!)

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Eventually these proteins make their way to the pet’s fur, or it could settle on your clothes, couches and carpets.

If you’re allergic to dogs, you might find yourself suddenly itching, coughing or wheezing when there’s one around. But what if you could better narrow down the dog you’re allergic to?

Is your friend’s female pug causing your sneezing attacks? Or is it the male Labrador retriever that’s triggering your allergy misery?

Now, there’s a precise allergy test ― called an in vitro allergen test ― that gives you details about whether you’re allergic to a female or male dog.

How the allergy test works

Ear, nose and throat specialist Michael Benninger, MD, says it’s sometimes hard to know if your allergic reaction is to furry animals in general, or if it’s to one very specific animal. The test can help identify what animal might be triggering your allergy attack.

This innovative test gives you much more information, unlike a skin test that may tell you that you’re allergic to cats and dogs when you’re actually, in fact, only allergic to one of them. It can assess your sensitivity to distinct types of furry animals, including dogs, cats and even horses.

The test can also pinpoint the exact protein that triggers your allergic reaction ― and from what animal or animals. And if you’re allergic to a male dog or female dog.

Advertisement

How is that possible? Dr. Benninger explains that about 40% of people who test positive for dog allergies are only allergic to prostate protein. And since only male dogs (obviously) have prostates, if everything else is negative, the person can be near a female dog and not have any sort of allergic reaction.

That means you can know which dogs to avoid. Or (yes!) which one you can adopt for your very own.

As of right now, testing for either male or female components is only available for dog allergies. But Dr. Benninger says the test is changing the game for allergies and helping to improve the quality of life for those that suffer from them.

Other uses for this type of allergy testing

This type of component allergy testing is quickly breaking new ground in common animal and food allergies involving proteins.

These specific protein tests can help to refine the major culprits in people who have multiple allergies where there may be overlap in traditional allergy tests, so that allergy avoidance can be maximized and treatment individualized.

The same test can also help determine serious, life-threatening reactions in those who have peanut allergies.

For example, about 77% of those who are allergic to peanuts are not at risk for anaphylaxis (a severe response including swelling, hives, lowered blood pressure and sometimes shock). This could help some of those PB&J lovers who don’t really have to avoid peanuts altogether.

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Bottles of essential oils alongside plants
June 12, 2026/Allergies

Essential Oils and Allergies: What the Science Says

The research is mixed, but experts agree: The risks outweigh the benefits

Field of white fluffy dandelions, with pollen floating in the breeze
June 2, 2026/Allergies

What Triggers Summer Allergies and How To Find Relief

Keeping your windows closed, showering before bed and using OTC allergy meds may help keep summer sniffles at bay

Person blowing their nose, surrounded by giant allergens, allergy medications and box of tissues
April 17, 2026/Allergies

Which Allergy Medicine Works Best?

The right choice for you depends on your symptoms, but options like nasal sprays and antihistamines can offer relief

Person blowing their nose walking by blooming tree
April 6, 2026/Allergies

A Sniffle for All Seasons: Is Allergy Season Ever Really Over?

When your allergies flare up depends on your location, immune health, personal triggers and more

Person and their dog lying on the couch, with air purifier running
March 20, 2026/Allergies

Home Remedies and Prevention Tips for Seasonal Allergies

Washing your sheets, rinsing your sinuses and running an air purifier are simple tricks for all-natural allergy relief

Hives on forearm, with possible allergy trigger foods on table, nuts, milk, eggs strawberries
March 3, 2026/Allergies

Can You Develop Allergies as an Adult?

A variety of factors, including changes to your body as you age, may lead to new allergies later in life

Pregnant woman taking allergy pill, with glass of water
December 23, 2025/Pregnancy & Childbirth

Seasonal Allergy Medicine You Can Take When You’re Pregnant

Most antihistamines, like Zyrtec, are OK, but avoid decongestants for at least the first trimester

Person injecting EpiPen into thigh
August 1, 2025/Allergies

EpiPen Alternatives You Should Know About

You can now get lifesaving epinephrine in a nasal spray and prefilled syringes

Trending Topics

Dry skin patch in background and person with eczema in foreground

Eczema vs. Dry Skin: What’s the Difference?

If you’re dealing with intense itching and red or swollen skin, it might be eczema

Panoramic X-ray of jaw and teeth

Teeth vs. Bones: Are They the Same?

While similar in some respects, teeth and bones have key differences, like durability and structure

Person applying olive oil on hand to get glue off skin

Sticky Situation: How To Get Super Glue Off Your Skin

Warm water, lotion, cooking oils or nail polish remover may all help to loosen the adhesive

Ad