August 29, 2023/Diabetes & Endocrinology

Are Artificial Sweeteners Safe for People With Diabetes?

Some sweeteners may have health risks, so it’s best to keep your intake moderate

Spoon dropping artificial sweetener into cup of tea, while diabetes test strip floats at right.

If you’re living with diabetes, you know limiting your sugar intake is important for managing your health. So, you do your best to cut out the added sugars and the simple carbs.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

And we know it’s not always easy.

So, when your sweet tooth comes calling, you naturally turn to food and drinks made with artificial sweeteners, right? Sweet taste, virtually calorie-free and all without spiking your blood sugar? Sounds like a dream come true.

“Used in moderation, artificial sweeteners can be safe for people with diabetes, and they can be used to reduce both your calorie and carbohydrate intake,” explains diabetes educator Sue Cotey, RN, CDCES. “Sugar substitutes also can help curb those cravings you have for something sweet.”

But as Cotey notes, that doesn’t mean foods made with artificial sweeteners are a particularly healthy choice.

For starters, you still need to focus on following a diabetes-friendly diet.

What’s more, some research shows certain sweeteners have been linked to health risks like cancer, heart attacks and stroke.

Does that mean you immediately need entirely cut out all sweeteners from your diet?

Probably not. But you should be thoughtful about how much artificial sweetener you eat.

Here, Cotey, along with Andrea Harris, RN, CDCES, also a diabetes educator, discuss some of the latest understanding about artificial sweeteners and share advice for people living with diabetes.

Diabetes-friendly sugar substitutes

Artificial sweeteners are popular among people with diabetes. They add sweet flavors to your foods without impacting your blood sugar in the way added sugars do. And many have zero calories.

You’ll find artificial sweeteners foods like:

You can also find them as stand-alone sweeteners in those various colored packages to add to your coffee or tea. Some are also available for cooking and baking.

Six artificial sweeteners have been tested and approved by the U.S. Food and Drug Administration (FDA) or placed on the agency’s Generally Recognized as Safe (GRAS) list.

“Artificial sweeteners undergo rigorous testing to confirm they are safe for consumption,” Harris says. “Being classified as GRAS means that, given the science we have, these products haven’t been proven to be harmful when used as intended.”

Sure, that’s a far cry from “health food” status. But it’s pretty clear indication the FDA doesn’t find artificial sweeteners to be wholly dangerous, especially if you don’t go overboard with them.


But in recent years, some research has shown some potential risks for some artificial sweeteners. Research is still ongoing, and some opinions vary regarding their use.

What does that mean for people with diabetes? Let’s dive a little deeper into some of the most common artificial sweeteners.


Also goes by: NutraSweet® and Equal® and “the blue packet.”

More than 200 studies support the safety of aspartame. But some recent results have been mixed. In 2023, a study of more than 100,000 people followed over eight years led the World Health Organization (WHO) to declare aspartame a possible cause of cancer.

For perspective, it’s listed as a Group 2B carcinogen, alongside things like lead and car exhaust. It’s a designation that means there’s evidence to support the idea that aspartame may be cancer-causing in certain situations, but there’s not yet enough evidence to know for sure.

“What is known is that aspartame is a source of phenylalanine, which is an ingredient people with phenylketonuria (PKU) should avoid,” Cotey explains. Packages of aspartame include that warning.

Aspartame isn’t heat-stable, so it’s not the best choice for baking or cooking.


Also goes by: Sweet ‘N Low®, Sweet Twin®, Sugar Twin® and “the pink packet.”

Non-human studies in the 1970s linked saccharin to bladder cancer. But they were dismissed by the FDA, as they weren’t relevant to people.

Saccharin is heat stable and a good choice for use in cooking, baking, canning and preserving.


Also goes by: Splenda®, N’Joy® and “the yellow packet.”

Like saccharin, sucralose is heat stable and easy to use in baking and cooking. It’s available to buy in dissolvable tablets, granular tablets and baking blends.


Also called: A Sweet Leaf®, Sun Crystals®, Truvia®, PureVia® and “the green packet.”

“Unlike most other artificial sweeteners, which are chemically manufactured, stevia is a sweetener derived from a plant,” Harris explains.

Some stevia products — ones that are created from whole stevia leaves — haven’t received GRAS status. They’re sold as dietary supplements, which don’t have to undergo rigorous scientific testing to prove their safety.


Other products — ones used as sweeteners in foods and beverages — have GRAS status. However, some stevia products include a sugar alcohol called erythritol, which has been linked to increased risk of heart attack and stroke. Research regarding this connection is ongoing.

Stevia comes in liquid and dissolvable tablets, as well as crystals.


Also goes by: Sunett®, Sweet One® and Ace-K.

Acesulfame-potassium is generally blended with another low-calorie sweetener.

It’s stable under heat, even under moderately acidic or basic conditions. It’s commonly used as a food additive in baking, or in products that require a long shelf life. In carbonated drinks, it’s almost always used in conjunction with another sweetener.


This product is mainly used by large food manufacturers, rather than a sweetener you’ll find at your local coffee shop or on grocery store shelves.

Neotame has 7,000 to 8,000 the sweetening power of sugar.

Like aspartame, neotame also contain phenylalanine. But it contains far less, so it doesn’t require a warning on its label.

Should people with diabetes avoid artificial sweeteners?

In a perfect world, we’d all avoid added sugars and artificial sweeteners. Your body doesn’t need sugar or artificial sweetener to keep you healthy. They have zero health benefits. They’re just not something that needs to be part of your diet.

In reality, though, an occasional sweet treat is just nice to have sometimes.

“Living with diabetes can come with major shifts in your eating habits,” Cotey notes. “Asking people to make a change like avoiding all sugar and all artificial sweeteners is a big ask. One that a lot of people won’t successfully keep up long-term.”

Most of the risks associated with artificial sweeteners are based on consuming very high quantities over long periods of time. So, Cotey and Harris’s best advice is to be thoughtful about your consumption. Keep your intake low, rather all-out banning sweetened foods.

“People with diabetes should be focused on eating well-balanced and properly portioned meals and snacks,” Harris states.

“Make sure you’re getting plenty of lean protein, non-starchy vegetables, healthy fats and complex carbs. And if you want a piece of sugar-free pie at a family celebration, you can. Just be thoughtful about your intake.”

Learn more about our editorial process.

Related Articles

Variety of cereals in different bowls
Here’s What To Know About Choosing Cereal if You Have Diabetes

There are better breakfast options, but if it’s got to be cereal, look for whole grains, high fiber and no added sugar

Hand holding glucose measurement device, with bottle of water in background at night
Are Religious Fasts Safe for People With Diabetes?

Planning ahead, checking in with your care team and being vigilant about blood sugar monitoring can help ensure a safe fast

healthcare provider writing in notes, with glucometer, blood droplet, medicine and approved foods floating near
How Stress and Depression Affect Diabetes

A diabetes diagnosis, new or long-standing, can trigger reactions like grief, stress, depression and frustration, but symptom relief and help are available

Person testing their blood sugar with their home kit
February 29, 2024/Diabetes & Endocrinology
Type 1 vs. Type 2 Diabetes: What’s the Difference?

Type 1 diabetes happens when your body doesn’t make insulin, while Type 2 happens when your body can’t use insulin properly

female healthcare provider speaking with patient in medical setting
January 10, 2024/Diabetes & Endocrinology
Can Too Much Sugar Cause Diabetes?

There is an indirect link between the sweet substance and the condition

person adding blueberries to bowl of granola cereal
January 8, 2024/Diabetes & Endocrinology
Can People With Diabetes Have Sugar?

The short answer: Yes, but you need to eat it in moderation and keep track of how much you consume

beer glass sitting beside diabetes testing equipment
October 11, 2023/Diabetes & Endocrinology
Diabetes and Alcohol: Do They Mix?

Blood glucose monitoring and drinking in moderation can help you avoid hypoglycemia

Grilled butternush squash on a white plate with kale and nuts sprinkled on top.
September 24, 2023/Eye Care
Foods To Eat for Diabetes-Related Macular Edema

Plant-based foods and healthy fats can help maintain and improve your eye health

Trending Topics

Person in yellow tshirt and blue jeans relaxing on green couch in living room reading texts on their phone.
Here’s How Many Calories You Naturally Burn in a Day

Your metabolism may torch 1,300 to 2,000 calories daily with no activity

woman snacking on raisins and nuts
52 Foods High In Iron

Pump up your iron intake with foods like tuna, tofu and turkey