Locations:
Search IconSearch

Can a Lip Filler Trigger a Cold Sore?

The short answer from a board-certified dermatologist

Lip filler injection on woman's mouth

Q: Can a lip filler trigger a cold sore?

A: If you’re prone to cold sores (herpes simplex virus), you’ve probably noticed that certain things can cause the virus to flare up. Stress, weather, chemicals and injury to the lip can all awaken the virus in your body. But needle punctures can be particularly triggering for cold sores.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Your dermatologist should ask about your history of cold sores when scheduling or considering a lip enhancement (or any procedure done around the mouth). If you’re prone to outbreaks, you’ll likely be prescribed an antiviral medication, such as valacyclovir (Valtrex®), to start taking a few days before the procedure. This medication will help to prevent a flare of the virus (even if you don’t have an active cold sore at the time).

You’re at the greatest risk of developing a cold sore from a lip enhancement procedure one to two days after injection.

Of course, you can be prone to cold sores, get a lip filler and have no sign of an outbreak. But it’s good practice to be precautious and minimize the risk.

Shilpi Khetarpal, MD

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Needle being injected into lips by gloved hands
December 4, 2024/Skin Care & Beauty

Lip Filler Aftercare: Dos and Don’ts To Help You Heal

An ice pack and acetaminophen can help tame initial discomfort

Closeup of person receiving hyaluron pen lip filler treatment.
September 1, 2023/Skin Care & Beauty

The Dangers of Hyaluron Pen Lip Fillers

Due to risks of bruising, scarring and infection, these needle-free injectors should be avoided

Baby chewing on teething ring
August 31, 2026/Children’s Health

How Can You Soothe Your Baby’s Teething Pain?

Massage, teething rings, chilled items and pain relievers can help dull the discomfort when baby teeth erupt

Person receiving cosmetic injection in forehead area
August 25, 2026/Skin Care & Beauty

Botox vs. Dysport: Is One Wrinkle Remedy Better Than the Other?

The treatments work in similar ways, but there are some slight differences that come down to your preference and goals

Person applying lotion after a shower
August 25, 2026/Skin Care & Beauty

How To Prevent Dry Skin This Winter

Moisturizing, running a humidifier and adjusting your shower routine may help keep itchiness and irritation at bay

Person emerging from the water sea side
August 12, 2026/Skin Care & Beauty

Is Saltwater Good for Your Hair and Skin?

Excessive exposure to saltwater can dehydrate skin and hair, despite having a few benefits

Person receiving Botox injections in their armpit
August 11, 2026/Skin Care & Beauty

Don’t Sweat It: How Botox Works To Limit Perspiration

Injections of Botox can significantly reduce sweating for up to a year, especially in your armpits

Person apply skin cream to their red and irritated elbow
August 7, 2026/Skin Care & Beauty

How To Choose the Best Eczema Cream

Look for emollients, humectants and occlusives to hydrate, soothe and protect your skin

Trending Topics

Two female college roommates in their dorm room

Is It True That Women’s Periods Sometimes Sync?

Your period may occasionally line up with someone else’s, but science suggests coincidence is responsible — not a mysterious biological connection

Healthcare provider talking with male patient

Male Enhancement: Can You Make Your Penis Bigger?

Most penis-enlargement products, devices and procedures deliver only modest (if any) gains

Pregnant woman at appointment with their healthcare provider

Gestational Diabetes Diet: What To Eat (and Limit) During Pregnancy

Make meals with lean proteins, non-starchy vegetables and complex carbohydrates

Ad