Locations:
Search IconSearch

Can a Lip Filler Trigger a Cold Sore?

The short answer from a board-certified dermatologist

Lip filler injection on woman's mouth

Q: Can a lip filler trigger a cold sore?

A: If you’re prone to cold sores (herpes simplex virus), you’ve probably noticed that certain things can cause the virus to flare up. Stress, weather, chemicals and injury to the lip can all awaken the virus in your body. But needle punctures can be particularly triggering for cold sores.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Your dermatologist should ask about your history of cold sores when scheduling or considering a lip enhancement (or any procedure done around the mouth). If you’re prone to outbreaks, you’ll likely be prescribed an antiviral medication, such as valacyclovir (Valtrex®), to start taking a few days before the procedure. This medication will help to prevent a flare of the virus (even if you don’t have an active cold sore at the time).

You’re at the greatest risk of developing a cold sore from a lip enhancement procedure one to two days after injection.

Of course, you can be prone to cold sores, get a lip filler and have no sign of an outbreak. But it’s good practice to be precautious and minimize the risk.

Shilpi Khetarpal, MD

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Needle being injected into lips by gloved hands
December 4, 2024/Skin Care & Beauty

Lip Filler Aftercare: Do’s and Don’ts To Help You Heal

An ice pack and acetaminophen can help tame initial discomfort

Closeup of person receiving hyaluron pen lip filler treatment.
September 1, 2023/Skin Care & Beauty

The Dangers of Hyaluron Pen Lip Fillers

Due to risks of bruising, scarring and infection, these needle-free injectors should be avoided

Person placing mouth device in their mouth
March 5, 2026/Oral Health

Can a Mouthguard Help TMJ Pain?

If you grind your teeth at night, a mouthguard might help relieve jaw discomfort

Person inserting a mouthguard
March 4, 2026/Oral Health

7 Tips To Stop Grinding Your Teeth at Night

Protect your teeth and ease strain with a nightguard, better sleep habits and other changes

Person applying lotion to eczema rash on hands
February 19, 2026/Skin Care & Beauty

Having an Eczema Flare-Up? Here’s What To Do

Eczema triggers are different for everyone, but there are some common ways to manage flare-ups, like using a humidifier and fragrance-free creams

Person in robe, hair wrapped in a towel, brushing their teeth at bathroom sink
February 13, 2026/Wellness

Wake Up Fresh: How To Stop Morning Breath

For fresher breath in the a.m., practice good oral hygiene, including flossing your teeth and scraping your tongue

Patient receiving a dental exam for a cleaning
February 12, 2026/Oral Health

How To Remove Plaque From Your Teeth

Daily oral hygiene goes a long way to keeping your mouth healthy and your smile bright

Dentist giving a child a dental exam/cleaning
February 12, 2026/Oral Health

When Do Kids Start Losing Their Teeth?

Most kids start losing baby teeth around age 6 — but there’s some wiggle room in the timeline

Trending Topics

Child playing soccer, being hit in head with soccer ball

The 6 Stages of Concussion Recovery

Getting back to normal after a head injury takes time — and patience

Caregiver helping happy child put on snow pants

Here’s How To Prevent Cold Stress

Dressing in multiple layers, drinking warm liquids and taking breaks indoors can help prevent these cold-weather injuries

Red, yellow and green bell peppers in baskets at market

Health Benefits of Bell Peppers

Pick bell peppers to help fight cancer, memory decline and joint pain

Ad