Locations:
Search IconSearch

Can a Lip Filler Trigger a Cold Sore?

The short answer from a board-certified dermatologist

Lip filler injection on woman's mouth

Q: Can a lip filler trigger a cold sore?

A: If you’re prone to cold sores (herpes simplex virus), you’ve probably noticed that certain things can cause the virus to flare up. Stress, weather, chemicals and injury to the lip can all awaken the virus in your body. But needle punctures can be particularly triggering for cold sores.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Your dermatologist should ask about your history of cold sores when scheduling or considering a lip enhancement (or any procedure done around the mouth). If you’re prone to outbreaks, you’ll likely be prescribed an antiviral medication, such as valacyclovir (Valtrex®), to start taking a few days before the procedure. This medication will help to prevent a flare of the virus (even if you don’t have an active cold sore at the time).

You’re at the greatest risk of developing a cold sore from a lip enhancement procedure one to two days after injection.

Of course, you can be prone to cold sores, get a lip filler and have no sign of an outbreak. But it’s good practice to be precautious and minimize the risk.

Shilpi Khetarpal, MD

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Needle being injected into lips by gloved hands
December 4, 2024/Skin Care & Beauty

Lip Filler Aftercare: Do’s and Don’ts To Help You Heal

An ice pack and acetaminophen can help tame initial discomfort

Closeup of person receiving hyaluron pen lip filler treatment.
September 1, 2023/Skin Care & Beauty

The Dangers of Hyaluron Pen Lip Fillers

Due to risks of bruising, scarring and infection, these needle-free injectors should be avoided

Person sitting on couch, scratching itchy skin on their arm, frowning

Could Your Itchy Skin Be a Sign of Cancer?

Persistent itching is usually caused by something harmless — but in some cases, it can point to certain cancers

Healthcare provider examining a mole with a magnifying glass on a patient

Does Skin Cancer Itch?

Skin cancer can sometimes itch, but it’s not usually the most common symptom — a persistent itch still warrants a visit to a healthcare provider

Skin with red dots and bumps
June 26, 2026/Skin Care & Beauty

‘Chicken Skin’: How To Get Rid of Bumps on Your Arms

With time and patience and trial and error, you may be able to find relief from keratosis pilaris (KP) symptoms

Baby's feet with a yellow-orange hue
June 23, 2026/Skin Care & Beauty

Carotenemia: What To Know About Orange Hands and Feet

Consuming too much beta-carotene can temporarily discolor your skin

Person applying olive oil on hand to get glue off skin
June 4, 2026/Skin Care & Beauty

Sticky Situation: How To Get Super Glue Off Your Skin

Warm water, lotion, cooking oils or nail polish remover may all help to loosen the adhesive

Healthcare provider examining plaques on patient's elbow
June 2, 2026/Skin Care & Beauty

GPP vs. Plaque Psoriasis: How To Tell the Difference

Plaque psoriasis builds over time, while GPP can appear suddenly with symptoms that may require urgent care

Trending Topics

Feet with socks on sticking out of blanket on a bed

Can Wearing Socks to Bed Help You Sleep Better?

Putting on socks at night can help regulate your core body temperature to bring on ZZZs

Assorted high-fiber foods in bowls on table, like broccoli, beans, nuts and leafy greens

What Foods Are High in Fiber?

Eating more legumes, fruits, vegetables, nuts and whole grains can help you meet your daily fiber goals

Person checking their health stats on their smartwatch, with checked off health goals, biohacking

What To Know About Biohacking and How To Try It Safely

Practices range from simple lifestyle changes to extreme experiments — and not all approaches come with the same level of risk

Ad