Locations:
Search IconSearch

Can a Lip Filler Trigger a Cold Sore?

The short answer from a board-certified dermatologist

Lip filler injection on woman's mouth

Q: Can a lip filler trigger a cold sore?

A: If you’re prone to cold sores (herpes simplex virus), you’ve probably noticed that certain things can cause the virus to flare up. Stress, weather, chemicals and injury to the lip can all awaken the virus in your body. But needle punctures can be particularly triggering for cold sores.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Your dermatologist should ask about your history of cold sores when scheduling or considering a lip enhancement (or any procedure done around the mouth). If you’re prone to outbreaks, you’ll likely be prescribed an antiviral medication, such as valacyclovir (Valtrex®), to start taking a few days before the procedure. This medication will help to prevent a flare of the virus (even if you don’t have an active cold sore at the time).

You’re at the greatest risk of developing a cold sore from a lip enhancement procedure one to two days after injection.

Of course, you can be prone to cold sores, get a lip filler and have no sign of an outbreak. But it’s good practice to be precautious and minimize the risk.

Shilpi Khetarpal, MD

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Needle being injected into lips by gloved hands
December 4, 2024/Skin Care & Beauty

Lip Filler Aftercare: Do’s and Don’ts To Help You Heal

An ice pack and acetaminophen can help tame initial discomfort

Closeup of person receiving hyaluron pen lip filler treatment.
September 1, 2023/Skin Care & Beauty

The Dangers of Hyaluron Pen Lip Fillers

Due to risks of bruising, scarring and infection, these needle-free injectors should be avoided

Person lying in tanning bed, closing it
July 2, 2026/Skin Care & Beauty

Unhealthy Glow: The Dangers of Tanning Beds

UVA rays from tanning beds increase your risk of skin cancer, wrinkles and eye damage

Person sitting on couch, scratching itchy skin on their arm, frowning

Could Your Itchy Skin Be a Sign of Cancer?

Persistent itching is usually caused by something harmless — but in some cases, it can point to certain cancers

Healthcare provider examining a mole with a magnifying glass on a patient

Does Skin Cancer Itch?

Skin cancer can sometimes itch, but it’s not usually the most common symptom — a persistent itch still warrants a visit to a healthcare provider

Skin with red dots and bumps
June 26, 2026/Skin Care & Beauty

‘Chicken Skin’: How To Get Rid of Bumps on Your Arms

With time and patience and trial and error, you may be able to find relief from keratosis pilaris (KP) symptoms

Baby's feet with a yellow-orange hue
June 23, 2026/Skin Care & Beauty

Carotenemia: What To Know About Orange Hands and Feet

Consuming too much beta-carotene can temporarily discolor your skin

Person applying olive oil on hand to get glue off skin
June 4, 2026/Skin Care & Beauty

Sticky Situation: How To Get Super Glue Off Your Skin

Warm water, lotion, cooking oils or nail polish remover may all help to loosen the adhesive

Trending Topics

Plate of chicken, broccoli and a baked sweet potato

Foods To Eat (and Limit) on a Diabetes Diet

Fill your plate with lean proteins, non-starchy vegetables and complex carbohydrates

Skin with red dots and bumps

‘Chicken Skin’: How To Get Rid of Bumps on Your Arms

With time and patience and trial and error, you may be able to find relief from keratosis pilaris (KP) symptoms

Child lying down asleep, with thumb in their mouth

How (and Why) To Help Your Child Stop Sucking Their Thumb

Thumb sucking is a normal part of early development, but over time, it can affect teeth, speech and habits

Ad