Locations:
Search IconSearch

Can Being Too Clean Weaken Your Immune System?

There’s no evidence that a short-term boost in hand-washing and cleaning will reduce your body’s immune function

Hands pumping hand sanitizer

In the quest to avoid the 2019 novel coronavirus, we’re going through bottles of soap and tubs of disinfectant wipes faster than some stores can restock them.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Along the way, there’s been some speculation on social media that all the hand-washing and disinfecting we’re doing in the name of keeping coronavirus away could be weakening our immune systems.

Are there really downfalls to being squeaky clean?

Allergist and immunologist James Fernandez, MD, PhD, says there’s no scientific evidence to suggest that temporarily stepping up your cleaning game is dangerous to your immune health.

“For adults, in this time frame we’re talking about and the hygiene measures that we’re taking, I don’t think there’s a lot of clinical risk to our immune system,” Dr. Fernandez says.

The hygiene hypothesis

The belief that a lot of cleaning and hand-washing weakens your immune system was probably born out of something called the hygiene hypothesis. This is the idea that kids who are exposed to more viruses, bacteria and other pathogens early in life build stronger immune systems.

“This idea comes from observations that some developing countries where kids might be exposed to more pathogens tend to have lower rates of certain diseases such as allergies and asthma,” Dr. Fernandez notes.

But there’s still debate around this hypothesis – and how much of a role personal hygiene plays. “Theoretically, it makes sense, but there isn’t a lot of strong science behind it,” Dr. Fernandez notes.

Advertisement

It’s also not meant to be interpreted as a sweeping generalization that more germs and less cleanliness are better.

Studies have repeatedly shown that keeping your hands clean is one of the best tools we have for reducing the spread of dangerous infectious diseases.

There are also many other factors that can affect your immune health that aren’t related to hygiene.

So, here’s the big takeaway: There’s no evidence that a short-term boost in hand-washing and cleaning will reduce your body’s immune function.

Scrub-a-dub-dub

To reduce the spread of the coronavirus and other infectious diseases, the U.S. Centers for Disease Control and Prevention (CDC) recommends washing your hands with soap and water after you’ve been in a public place or after blowing your nose, coughing or sneezing. If you need to wash your hands but soap and water aren’t available, use a hand sanitizer made with at least 60% alcohol.

Washing and sanitizing your hands a lot can leave your skin dry or cracked, so you might want to add a good moisturizing lotion to your hand-washing routine.

The CDC also recommends regularly cleaning frequently touched surfaces in your household, including doorknobs, light switches, countertops and faucets.

Proactively protect your immune health

Hygiene aside, there are many factors that play into how well-equipped your immune system is to fight infections. Some of those things are out of your control, such as age and genetics. But there are several things you can do to keep your defenses strong, including:

  • Find ways to cope with stress. Stress causes your body to make a hormone called cortisol. Over time, cortisol can lead to inflammation and reduce your body’s ability to fight off infections.
  • Fuel up smartly. A well-rounded diet with ample amounts of fiber and healthy fats helps keep inflammation at bay.
  • Keep moving. Regular exercise helps keep your immune system running smoothly.
  • Get your ZZZs. The average adult needs about seven to nine hours of sleep a night.
  • Avoid harmful substances. Smoking and excessive drinking can weaken your immune system.

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Person standing outside bundled up in below zero weather with snow

How Cold Weather Can Weaken Your Immune System

Cold, wet conditions can weaken your immune system, which makes it easier for illnesses and infections to spread

Assorted immune boosting foods, with ginger, citrus, blueberries and spinach

12 Foods That Help Boost Your Immune System

Options like fatty fish, citrus fruits and sunflower seeds can help keep you well and heal faster

woman eating an orange to boost immunity

Strengthen Your Immune System With 4 Simple Strategies

From boosting foods to lifestyle changes to a healthy attitude

Healthcare provider examining child's throat
June 15, 2026/Ear, Nose & Throat

Removing Tonsils and Adenoids: Is It Right for Your Child?

These surgeries may be recommended if your child has obstructive sleep apnea or frequent throat infections

Hand pumping liquid soap from bottle onto other hand
June 2, 2026/Primary Care

Should You Be Using Antibacterial Soap or Regular Soap?

Antibacterial soap hasn’t been shown to be any more effective at killing germs than regular soap and water

Healthcare provider adjusting IV fluid, with patient nearby
June 1, 2026/Skin Care & Beauty

When a GPP Flare Needs Urgent Care

Signs like fever, breathing problems and muscle weakness, along with red patches and pus-filled bumps, mean it’s time for emergency treatment

Wallet, credit cards, change and money laid out
May 29, 2026/Infectious Disease

How Dirty Is Your Money? And Should You Be Washing It?

Your dollar bills, coins and cards are covered in germs — but they’re very unlikely to make you sick

Person sitting on couch, head in hand, hand on stomach, doubled over

4 Early Signs That May Signal a Systemic Mastocytosis Flare

Some flares begin with subtle changes, like flushing, agitation or a strange metallic taste, before more serious symptoms appear

Trending Topics

Person doing glute bridges with band resistance

Build Lower-Body Strength One Bridge at a Time

Glute bridges are simple bodyweight exercises worth adding to any workout

Healthcare provider with clipboard, with lab vials, meds, oversized prostate and prostate cancer ribbon

What It Means To Have Advanced Prostate Cancer

Cancer that’s spread beyond the prostate is considered ‘advanced’

Fish market worker selecting a cut of fresh fish

Best Catch: The Healthiest Fish To Eat

The best choices are high in omega-3s and protein and low in mercury

Ad