Locations:
Search IconSearch

Can Statins Actually Reverse Plaque Buildup?

The short answer from a cardiologist

plaque buildup in blood vessel statin

Q: Can statins actually reverse plaque buildup?

A: Yes. There have been several clinical studies — many of them done here at Cleveland Clinic — that show statins can reverse plaque buildup.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Two statins in particular, atorvastatin, which is sold under the brand name Lipitor, and rosuvastatin, which is sold under the brand name Crestor, are the strongest statins.

Clinical studies using ultrasound in the coronary arteries have shown that when you are on high doses of these medicines, even if you have plaque buildup already, you can stabilize the plaque on statin therapy.

If your LDL cholesterol is lowered below 70 mg/dL, you can even see a regression in the plaque by up to 24%. So having really a low LDL cholesterol level can help stabilize any plaque buildup you have, and prevent further plaque progression.

— Cardiologist Steven Nissen, MD

Advertisement

Learn more about our editorial process.

Related Articles

close up of bottle of pills spilling onto table
January 24, 2024/Heart Health
Take Your Cholesterol Meds: Stopping Statins Can Cause Dangerous Side Effects

Stopping this critical medication on your own increases the risk of heart attack, stroke and more

Familial high cholesterol
April 7, 2022/Heart Health
Is High Cholesterol Hereditary?

Your family tree may increase your risk of high cholesterol and heart disease

A bowl of granola with a big slice of apple
March 8, 2022/Heart Health
How to Naturally Lower Your Cholesterol

From fish to fiber to fitness, a cardiologist shares proven tips

An illustration of a person sitting on a couch with their head in their hands
February 18, 2022/Heart Health
Can High Cholesterol Cause Headaches?

Find out if there’s a link between these two conditions

niacin and choletesterol
November 16, 2020/Heart Health
Can Niacin Be Harmful to Control Cholesterol?

Studies reinforce its role in specific types of patients

Legs and feet of person on a treadmill at the gym
March 3, 2025/Heart Health
High Resting Heart Rate? Here’s How To Slow It Down

Lifestyle changes can help strengthen your heart so it doesn’t have to work as hard when your body is at rest

Oversized alarm clock, with portion sectioned with food, and the rest with water, with person in fitness attire next to it
February 27, 2025/Heart Health
What Intermittent Fasting Can Do for Your Heart

Studies show intermittent fasting may help you lose weight, improve blood pressure and more

Older man and older woman riding bikes in park
February 24, 2025/Heart Health
Can You Exercise With a Leaky Heart Valve?

Most people with this heart condition can and should exercise, but check with your provider to see what (and how much) is safe for you

Trending Topics

Person in bed sleeping on their side, covers off
Breathing Problems? Try These Sleep Positions

If you’re feeling short of breath, sleep can be tough — propping yourself up or sleeping on your side may help

A couple looking at skyline, with one person slightly behind the other, head bent down
What Is Anxious Attachment Style — and Do You Have It?

If you fear the unknown or find yourself needing reassurance often, you may identify with this attachment style

Glasses and bottle of yellow-colored prebiotic soda, with mint, lemon and ginger garnish
Are Prebiotic Sodas Good for You?

If you’re looking to boost your gut health, it’s better to get fiber from whole foods

Ad