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Which Drops Are Best for Your Itchy, Red or Dry Eyes?

How and when to use over-the-counter drops

safe eye drops being put into eye

Itchy, watery eyes are the worst. But what’s even more troublesome is arriving at your local pharmacy to find so many over-the-counter eye drops to choose from. How do you know which eye drops will work best for you?


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Ophthalmologist Peter McGannon, MD, breaks down eye-drop products into three categories based on their active ingredients.

1. Allergy drops

How they work: When you have an allergic reaction — say to pollen, dust, or animal dander — your body releases histamines. These tell your body that allergens have invaded it, and, in response, your body triggers the classic allergy symptoms: runny nose and itchy, watery eyes.

Dr. McGannon explains that allergy eye drops work by blocking the histamine response in your body altogether.

“These drops block the overreaction of the body to allergens,” he says. Allergy eye drops most commonly contain an antihistamine (like pheniramine or naphazoline) or a newer, long-acting antihistamine (such as olopatadine or ketotifen), which prevent your body from releasing histamines in the first place.

Use: Allergy drops help reduce the redness, itching and watering from seasonal allergies from your eyes. Use, as needed, according to the instructions on the label.

2. Anti-redness drops

How they work: These shrink the blood vessels on the surface of the eye — a process called vasoconstriction — that makes the redness go away. “Typically these drops may occasionally contain allergy relievers and mild lubricants,” says Dr. McGannon.


Use: As the name indicates, these help reduce the redness of irritated eyes. They’re okay for occasional use. But use caution: Overuse may make your eyes dependent on them, and they may make your redness worse if you use them for many days in a row. Dr. McGannon adds, “Using redness relievers regularly for chronically red eyes may mask more serious eye problems that need to be addressed by a doctor.”

3. Artificial tears

How they work: If you have super dry eyes that feel itchy and gritty, artificial tears can bring relief. Artificial tears’ main focus is keeping your eyes moist and lubricated. “They are made to mimic the way real tears work in the eye,” says Dr. McGannon. They contain electrolytes and lubricants to keep your eyes lubricated and healthy. Use: Use them, as needed, to treat dry eye or to ease contact lens irritation or mild allergies. However, don’t confuse artificial tears with anti-redness drops, which you should use only sparingly, Dr. McGannon says.

More about dry eye

Chronic dry eye can indicate a larger problem within the body. Dry eye is a common problem, especially as we get older. While contact lens wearers often experience dryness and irritation, women may experience dry eye after menopause because of hormonal changes.

“Symptoms of dry eye are typically scratchy, gritty, burning eyes or intermittent blurring, especially while reading or looking at screens,” says Dr. McGannon. “But contrary to what most people think, tearing is one of the most common signs of dry eyes.”

Tears are a reaction to dry eye, but these reactive tears are too watery and don’t lubricate the eye well, he says.

Sorting out terms on eye drop labels

Dr. McGannon says generic store brands generally work as well as name-brand products for eye drops.

However, be wary of drops labeled “natural,” “homeopathic” or “herbal.” While they could work well for you, there is no reliable data to support their use or effectiveness, he says.

When should you see a doctor?

If you have seasonal or pet allergies that have been well-documented by your doctor, using over-the-counter eye drops, as needed, are appropriate.

“But if you have unexpected eye irritation after a recent upper respiratory infection or exposure to someone with a red eye, then there is a high probability of a viral or bacterial infection,” says Dr. McGannon.

“Eye conditions that are not improving with over-the-counter products, are quickly worsening, or are accompanied by severe pain or vision changes or loss should be evaluated by a doctor right away,” he says.


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