July 31, 2020

Do Bug Sprays Actually Work?

And find out if they're safe or not

woman applying bug spray while on a hike

Like a moth to a flame, biting insects are there to ruin every warm-weather affair. So how do you make them scram so you can enjoy the great outdoors? Family medicine specialist Donald Ford, MD, shares the science behind bug sprays and gives tips to help you avoid becoming their catch of the day.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

How bug sprays work

When you put bug repellent on your skin, it immediately starts evaporating, forming an invisible cloud of chemicals around you. (Think: Pig-Pen from Charlie Brown.)

“Insects perceive these chemicals in the air and stay away,” says Dr. Ford.

Why you should use mosquito repellent

When it comes to bug bites, an ounce of prevention is worth a pound of cure. Insect bites range from annoying to deadly — they can also be irritating, painful and ultimately lead to disease.

“There are significant mosquito-borne diseases. We don’t see too many in the northern part of the United States. They exist more in the southern United States, southern parts of the world, the Caribbean and South America,” says Dr. Ford. “Malaria is the most well-known and causes the most damage. Yellow fever has also been a significant problem worldwide.”

Other illnesses caused by biting insects include:

  • Zika virus (a mosquito-borne illness found in South America, Central America, Mexico and the Caribbean).
  • West Nile virus (the leading cause of mosquito-borne disease in the continental U.S., according to the CDC).
  • Lyme disease (a tick-borne illness common in the northeastern and upper midwestern U.S.).
  • Anaplasmosis/ehrlichiosis (closely related tick-borne illnesses found in the Northeast, Mid-Atlantic, and south-central and upper Midwest).

What is the most effective bug spray?

On the shortlist of effective bug repellents, two active ingredients reign supreme:

  • DEET (N,N-diethyl-m-toluamide): Dr. Ford says most people use bug sprays with DEET because they’re the most effective. “You don’t know what insects you’re going to come across, so using the agent that’s effective against the widest variety is the best strategy.”
  • Picaridin (KBR 3023): Dr. Ford notes that picaridin, more popular outside of the U.S., is effective. “But picaridin needs to be used in higher concentrations than DEET.”

And if you’re looking for a one-two punch, Dr. Ford says the insecticide permethrin is fairly effective. However, you need to use it very carefully.

“You can either buy permethrin-treated clothing or apply it to clothing yourself. That plus DEET is the most effective strategy for repelling insects. You should not apply permethrin directly to the skin, but once it’s dried on clothing, it’s OK to wear.”

Is bug spray bad for you?

While bug sprays sometimes get a bad rap, Dr. Ford says they are safe. “The amount of chemicals absorbed into the skin is very low. Even in those low amounts, there are no recognized toxic effects.”

In fact, the U.S. Environmental Protection Agency (EPA) has said DEET is safe for use in both children and adults. “The harm comes when people ingest these chemicals,” notes Dr. Ford. “So use caution when applying repellents on children since kids are more likely to touch their skin, put their hands in their mouth or touch their eyes. We also recommend washing your hands after you apply. And use products labeled safe for children because they have slightly lower chemical concentrations.”


Are natural mosquito repellents and bug sprays effective?

Not sold on chemical bug sprays? Dr. Ford says the oil of lemon eucalyptus is the way to go if you prefer all-natural repellents.It comes from the leaves of the lemon eucalyptus tree, which grows in Australia. “Its active ingredient is PMD (para-menthane-3,8-diol), but it’s thought to be less effective than DEET and picaridin,” he says. “Beyond that, no other oils or natural products have been proven effective. That includes citronella, which sometimes is sold for use on the skin or as a candle.”

Related Articles

Blood pressure cuff on arm and blood pressure-reading device
February 27, 2024
Here’s What Your Blood Pressure Numbers Mean

An ideal blood pressure is less than 120 mm Hg systolic and less than 80 mm Hg diastolic

Tired cancer patient reading at night
February 27, 2024
The Link Between Insomnia and Cancer Treatment

Medications, tubing and stress can steal away the ZZZs you need

Person taking heart health quiz on a clipboard
February 26, 2024
How Healthy Is Your Heart? Take This Quiz To Find Out

Age, sex and genetics are just a few factors that can affect your risk of developing coronary heart disease

Cholesterol blocking blood flow in artery
February 26, 2024
What It Means if You Have ‘Sticky’ Cholesterol

LDL cholesterol and lipoprotein (a) cholesterol are more likely to stick to your arteries and lead to dangerous heart events

Person holding cup of hot tea, with honey jar floating in background
February 23, 2024
Why Your Throat Tickles — And How To Stop It

Often, a throat tickle is due to a cold, allergies or GERD — but see a doctor if it won’t go away

Close up of person pouring a cup of coffee
February 23, 2024
Does Caffeine Help Headaches?

It’s all about the amount — try to stick to 100 to 150 milligrams a day to reduce and prevent a pounding, throbbing head

Female asleep on couch on backyard deck next to laptop and glasses
February 22, 2024
Does Breast Cancer Treatment Make You Tired?

The answer is yes — but there are things you can do to help boost your energy

blurred person looking out window in background with glass of wine and bottle in foreground
February 21, 2024
How Does Alcohol Affect Your Brain?

Even one drink can have an impact on your cognitive function leading to slurred speech, blurred vision and impaired memory

Trending Topics

close up of keto gummies
Do Keto Gummies Work for Weight Loss? Are They Safe?

Research is inconclusive whether or not these supplements are helpful

Person in yellow tshirt and blue jeans relaxing on green couch in living room reading texts on their phone.
Here’s How Many Calories You Naturally Burn in a Day

Your metabolism may torch 1,300 to 2,000 calories daily with no activity

Older person postioned sideways showing dowager hump.
Dowager’s Hump: What It Is and How To Get Rid of It

The hump at the base of your neck may be caused by osteoporosis or poor posture