Locations:
Search IconSearch

Injections That May Ease Your Joint Pain

Several options to help get you moving

Joint Pain Knee Injection

If you’re one of the 30 million adults in the United States who live with joint pain, you know it’s often debilitating. It can keep you from staying active and even make daily chores seem impossible. What you might not know is that your doctor can treat you with more than pills or surgery.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Depending on the severity of your pain, injections can be another option for easing your joint pain and get you moving again, says sports and medical orthopaedist Jason Genin, DO.

“In many cases, we use these injections to try to reduce inflammation and pain in your joints,” Dr. Genin says. “With some treatments, you often can experience fewer symptoms for several months.”

There are several injectable options to help treat knee pain. “The injections range from corticosteroids, which have been around for decades, to newer cellular therapies like platelet-rich plasma (PRP),” he says.

Your physician will decide which one is best based on your individual needs, says sports and medical orthopaedist Dominic King, DO.

“Not every injection is right for every patient,” Dr. King explains. “We take a lot of time to understand your specific issues and create an injectable plan that works with your entire knee care path.” This can include weight loss, exercise, stretching, activity modification, anti-inflammatory medications, as well as injection therapy.

Types of injection therapy available

Corticosteroid injections

Traditional injections, such as corticosteroids (“cortisone”), can be effective — particularly in the late stages of arthritis, as a way to get past a sudden increase in pain and delay the need for surgery.

Hyaluronic acid injections

Hyaluronic acid (HA) injections often are used when corticosteroid injections don’t work. But they usually are approved only for use in the knee.

In some instances, doctors consider HA injections first if you don’t have obvious signs of inflammation. HA also is a better option if you have diabetes, as corticosteroids can raise blood sugar levels.

Also known as gel injections, HA injections are chemically similar to your natural joint fluid.

When you have osteoarthritis, joint fluid becomes watery. So, this injection helps to restore the fluid’s natural properties and works as a lubricant and a shock absorber.

“HA is a cushion or a buffer against inflammatory cells in the joint,” Dr. Genin says. “In some cases, it can stimulate the knee to start producing more natural HA.” Some physicians also believe that HA helps reduce pain by coating nerve endings within the joint.

One treatment, which may consist of between one and three injections, usually offers symptom relief for four to five months, but sometimes up to one year. However, pain and stiffness will return. Most insurance companies only approve one HA injection every six months.

Advertisement

Platelet-rich plasma (PRP) injections

Platelet-rich plasma (PRP) injections are a newer alternative to treat osteoarthritis joint pain. Cells from the patient’s own blood are processed in a centrifuge to remove red blood cells and most white blood cells, concentrating the platelets. “A growing body of evidence has shown that PRP can be as effective or more effective than anti-inflammatory medications or cortisone, particularly in the early stages of arthritis,” Dr. Genin adds.

Side effects of injection therapies

Side effects include a very low risk of infection and pain at the injection site. You also must stop taking oral anti-inflammatory medications for a short amount of time if you get a PRP injection, Dr. Genin says.

“Often, many of these injections are effective in reducing or stopping your joint pain, but it’s important to remember that they may not keep the pain from returning, Dr. King notes. In fact, they’re most effective when used with other therapies. And we consider surgical options only if other treatment options have failed.”

Advertisement

Learn more about our editorial process.

Related Articles

Healthcare provider listening to a patient's heart with stethoscope in exam room
Is Joint Pain Linked to Heart Disease?

Research shows a strong association between rheumatoid arthritis and heart issues

person applying ointment to eczema on arm
December 13, 2023/Skin Care & Beauty
When Home Remedies Won’t Do: Treatment Options for Severe Eczema

Steroids, self-injections and medications can be game changers

someone putting kinesiology tape on another's knee
September 4, 2023/Exercise & Fitness
Can Kinesiology Tape Help Your Athletic Performance?

Elastic therapeutic tape can provide extra support, but it can’t improve your stats

Patient with back pain walking into doctor's appointment while doctor holds door.
August 1, 2023/Chronic Pain
7 Causes of Chronic Pain

Arthritis, migraines and endometriosis are common causes of chronic pain

woman's knee aches during weather changes
January 15, 2023/Chronic Pain
How Changes in Weather Affect Joint Pain

Barometric pressure can play a role in joint pain, but that doesn’t mean you have to live with it

man in pain after sleeping
January 12, 2022/Chronic Pain
How To Keep Sore Hips, Knees and Shoulders From Ruining Your Sleep

Find the right sleep position to tame your joint pain

Drawing of a person with question marks in thought bubbles
December 12, 2021/Rheumatology & Immunology
Can You Have Psoriatic Arthritis Without Psoriasis?

The link between joint pain and skin rashes

healthcare provider readying a cortisone shot
October 13, 2020/Orthopaedics
Q&A: Can Cortisone Injections Ease My Joint Pain?

Find the answers to some of these common questions

Trending Topics

Female and friend jogging outside
How To Increase Your Metabolism for Weight Loss

Focus on your body’s metabolic set point by eating healthy foods, making exercise a part of your routine and reducing stress

stovetop with stainless steel cookware and glassware
5 Ways Forever Chemicals (PFAS) May Affect Your Health

PFAS chemicals may make life easier — but they aren’t always so easy on the human body

jar of rice water and brush, with rice scattered around table
Could Rice Water Be the Secret To Healthier Hair?

While there’s little risk in trying this hair care treatment, there isn’t much science to back up the claims

Ad