Some Medications Can Make Your Skin Sensitive to the Sun

Does your skin have an extreme reaction when you spend time in sunlight or artificial ultraviolet light? If so, it may surprise you to know that the medications you take may cause this intense sensitivity. And sunscreen is likely only part of the solution.

“The reaction can present as exaggerated sunburn or as eczema-like red, itchy spots,” says dermatologist Anthony Fernandez, MD, PhD. “And if you think you can protect yourself by loading up on sunscreen, you should know that you’ll probably need more protection than the average person.”

Why do some medications cause photosensitivity?

Different medications (including pills and those applied to the skin or injected) cause photosensitivity for different reasons.

“For the most part, the combination of the drug and the ultraviolet light (both UVA and UVB) from the sun generates toxic and inflammatory reactions that are harmful for skin cells,” explains Dr. Fernandez.

What photosensitivity looks like

The most common reaction, known as phototoxicity, causes a sunburn-like effect on skin when you go out in the sun. Your skin may react shortly after you go out in it or it may take up to 24 hours to show up.

The itchy rash — a photoallergy — isn’t as common. It typically appears a few days after you’re out in the sun. The rash sometimes even shows up on skin that wasn’t directly exposed.

Common medications that can cause sun sensitivity

Both prescription and over-the-counter drugs can cause a reaction, including very common ones like ibuprofen and birth control pills.

“Some of the commonly used drugs include antibiotics such as trimethoprim (Bactrim®) or ciprofloxacin and some diabetes medications (including glipizide, glyburide and glimepiride),” Dr. Fernandez says.

Your skin may react to other drugs, too, including:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) used for arthritis.
• Pain relievers, such as naproxen, diclofenac and piroxicam.
• Diuretics used for blood pressure, like furosemide and thiazides.
• Certain antihistamines, like promethazine, which is also used to treat motion sickness.
• Anti-arrhythmic drugs to treat irregular heartbeat, such as amiodarone and quinidine.
• Acne medications, like tretinoin and isotretinoin.
• Tricyclic antidepressants, like amitriptyline and nortriptyline.
• Methotrexate, a medication that treats psoriasis and osteoarthritis.

But that’s not all! There is a wide range of medications that can cause sun sensitivity, from antifungals and cholesterol-lowering drugs to tranquilizers.

If you’re wondering whether or not photosensitivity is a side effect of a medicine you’re currently taking, you can check out the U.S. Food and Drug Administration’s (FDA) list of medications that can cause sun sensitivity.

Risk factors for sun sensitivity

While there are a lot of medications out there that have the potential to cause phototoxic or photoallergic reactions, whether or not they will can be hard to predict.

According to Dr. Fernandez, two people can take the same medication and one person might see a reaction, while the other doesn’t. To make things still more complicated, your skin may react every time you take the medication and go out in the sun, or it may only happen once.

“People with fair skin, blond or red hair and blue eyes are more sensitive to sunlight in general,” notes Dr. Fernandez. “However, anybody can get an exaggerated sunburn due to medications, regardless of skin color.”

How to prevent medication photosensitivity

“The best way to minimize these reactions is strict sun protection and avoiding excessive sun exposure,” he advises. “Even sunlight exposure through windows at home or while driving can cause a reaction.”

Sunscreen protects against some harmful rays. According to the American Academy of Dermatology Association, it is most effective if:

• It’s broad-spectrum, protecting against both UVA and UVB light.
• You put it on 15 to 30 minutes before going out in the sun.
• You reapply it every two hours.
• You make sure to use enough — use at least 1 ounce of sunscreen to cover your entire body.
• Double-check your sunscreen’s expiration date.

Avoid going out in the sun during the peak hours of intensity — between 10 a.m. and 2 p.m. And while sunscreen helps, wearing protective clothing, such as a broad-brimmed hat and long sleeves, is a better strategy to minimize the risk of drug-induced sunburns.

Check with a healthcare provider or pharmacist if you’re not sure whether the medications you take may pose a risk. And remember: Even if you’re not on any medications, you should still always protect your skin when you’re in the sun.