Locations:
Search IconSearch

5 Strange Places You Can Get Melanoma

See where the deadliest skin cancer can develop

Think melanoma strikes only the typical sun-exposed areas of your skin? This deadly cancer can surface in surprising places, says dermatologist Christine Poblete-Lopez, MD:

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Melanoma arises from melanocytes (cells that give us pigment). They are everywhere you’ve got skin. So, although it’s rare, melanoma can develop in your belly button, armpits and groin.

Navel-Melanoma

Yes, you also have melanocytes in your nail beds, feet and hands. Melanomas in these areas are more aggressive, likely due to a delay in diagnosis. They are more common among Asians and African-Americans.

Nail-Melanoma

Melanocytes also inhabit the colored iris of your eye, and you can develop melanoma there. When anyone develops melanoma, routine eye checks are as vital as skin checks.

Eye-Melanoma

It’s rare, but melanomas can develop in your body’s mucous membranes. These line your mouth, throat, genitalia, urinary tract, anus and rectum.

Oral-Melanoma

A full head of hair helps protect your scalp from the sun. But once hair starts to thin, melanoma can develop there, especially on the crown of the head.

Scalp Melanoma

You can’t blame melanoma entirely on the sun’s ultraviolet rays. Genetics also play a role. Multiple sunburns and exposure to tanning beds also increase your risk.

Tanning Bed - open and lights switched on

Apply sunscreen daily, just like you brush your teeth. Reapply it when going outdoors. For full protection, you should also wear sun-protective clothing, seek shade, and avoid direct sun between 10 a.m. and 3 p.m. (You can get vitamin D from supplements.)

Advertisement

Applying sunscreen to arm

Advertisement

Cleveland Clinic icon
Health Essentials logo
Subscription icon

Better health starts here

Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.

Learn more about our editorial process.

Related Articles

Dermatologist using magnifying tool to look at spot on person's back
December 11, 2024/Cancer Care & Prevention
What To Know About Recurrent Melanoma

The likelihood of melanoma returning varies by stage, but you can take steps to help prevent recurrence by wearing sunscreen and monitoring your moles

Ringworm on the skin, with a smear of antifungal cream by it, ready to be rubbed in
February 11, 2026/Skin Care & Beauty
How To Get Rid of Ringworm: A Quick Guide

Over-the-counter antifungal creams usually get the job done, but it’s important to keep it from spreading in the meantime

Beef tallow in jar on counter, with spatula
February 10, 2026/Skin Care & Beauty
Beef Tallow for Skin: Is It Useful?

Although it could be used as a moisturizer, this new trend is not recommended

Person applying skin care cream, with bottle, tube and jar of cream floating nearby
February 6, 2026/Skin Care & Beauty
Top 6 Benefits of Niacinamide

The popular skin care ingredient can help smooth, brighten and strengthen your skin

Veggies in strainer in sink with water running, with bottle of hydrogen peroxide and mixing bowl on counter
January 16, 2026/Skin Care & Beauty
Hydrogen Peroxide: When To Use It and When To Skip It

It’s a great disinfectant for around your home, but not for your skin

Different types of makeup, including mascara, blush, eyeliner and more
January 15, 2026/Skin Care & Beauty
When Does Your Makeup Expire?

Changes in texture, smell, color and performance are signs it’s time to throw the cosmetic item away

Hand being wrapped in gauze by healthcare provider wearing disposable medical gloves
January 14, 2026/Skin Care & Beauty
First Aid Treatment for Burns

Follow the 4Cs — cooling, cleaning, covering and comforting — to start the healing process

Large shower head with water running out
January 6, 2026/Skin Care & Beauty
How Often Should You Shower?

Bathing once a day is the general guidance, but you could also have reasons to soap up twice a day or not at all

Trending Topics

An older couple walking their dog outside
How Nature Can Improve Your Mental Health

Even small moments of time outdoors can help reduce stress, boost mood and restore a sense of calm

Person wearing glasses outdoors, looking around
Myth Busting: No, Glasses Don’t Make Your Eyes Worse

A correct prescription helps your eyes see clearly — but as natural changes occur, you may need stronger or different eyeglasses

Person seated on sofa, holding chest in pain
Cardiac Arrest vs. Heart Attack: What’s the Difference?

Both are medical emergencies, but they are very distinct events with different causes

Ad