May 7, 2023/Skin Care & Beauty

A Deep Dive on Depilatory Creams

This old-school hair removal method is painless if done correctly — but it’s not for everybody

Person using a dipiliary cream on their leg while draped in a towel in the bathroom.

Humans are creative. Especially when it comes to removing unwanted hair. Shaving. Waxing. Plucking. Sugaring. Threading. Crystal hair erasers. Lasers. We’ve done it all in the quest to find the most efficient, effective and painless fuzz-fighting technology.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Depilatory creams — one of the older approaches in the hair-removal pantheon — have been around for nearly a century now. We talked to aesthetician Lori Scarso about the risks and benefits of using them.

What are depilatory creams?

Depilatory creams use thioglycolic acid to break down the keratin protein in your hair. When you rinse the product off, the hair comes off with it.

Depilatory creams don’t remove the hair at the root like waxing and threading do. Instead, they make the hair structurally unstable; where exactly the hair breaks under the skin can vary. So, you can expect the hair to regrow faster than it does with waxing, but slower than it does with shaving.

Side note: Depilatory creams may be pain-free, but they aren’t always stink-free. One of the most commonly used ingredients in depilatory creams smells like rotten eggs, which … can be alarming the first time you experience it.

Benefits of using depilatory creams vs. other hair removers

When it comes to removing unwanted hair, our needs and preferences vary. What matters most is what works best for you. That said, if you asked a depilatory cream devotee why they use these products, they’d probably say something along these lines:

Painless and user-friendly (most of the time)

Waxing, plucking, threading, sugaring — they all hurt a bit. Sure, shaving doesn’t hurt in theory, but it’s rare to get through all of your shaving sessions completely free of nicks and cuts.

But depending on your skin type, depilatory creams can be completely painless!

(There are definitely people who can’t comfortably use depilatory creams — we’ll come back to that in a bit.)

Another point in depilatory creams’ favor: They’re user-friendly. Just make sure you do a patch test first. From there, as long as you follow the directions on the box, bottle or tube to the letter, you should be good!

Skin and hair effects

Scarso explains that, unlike most hair removal techniques, depilatory creams actually penetrate into the skin. As a result, they tend to be loaded up with moisturizers. It’s also often the case that the hair comes back slightly finer than it was to begin with.

A DIY hair-removal option

If the idea of paying somebody to remove unwanted hair from your face or body doesn’t appeal, depilatory creams are a great option. You use them in the comfort and privacy of your own bathroom. And you don’t have to tip!


An affordable option

Depilatory creams are more affordable than some of the other hair-removal techniques out there.

Yes, the cost of buying these products adds up, but any option that removes hair below the surface will last longer than shaving. And depilatory creams are definitely a more affordable option than going to a salon or spa.

Prices vary from brand to brand, and depending on the type of hair the cream’s formulated to target. And it’s worth noting that while products marketed “for men” tend to be more expensive, the product is the same.

An accessible option

If you’re scared of using a razor — or manual dexterity is a concern — depilatory creams are a great at-home alternative to shaving.

Risks of using depilatory creams

Remember the active ingredient in depilatory creams: Thioglycolic acid. While generally safe, the potential side effects that come with using depilatory creams are more severe than most hair-removal techniques. Left on too long, these creams can cause first-, second- or even third-degree chemical burns. That’s why it’s extra important to do the following:

Buy the right product

For example, don’t ever try to remove your facial hair — or, gasp, your pubic hair — with a depilatory cream designed for leg hair. There are different depilatory creams for different kinds of hair and skin. Putting it on the wrong body part is an easy way to end up with a chemical burn, so be sure to use the product as indicated.

Follow the instructions to the letter

“It’s very important to follow the manufacturer’s instructions regarding the length of time you keep the product on, which is usually between five and 10 minutes,” Scarso urges. Leaving the product on longer is likely to result in chemical burns.

It’s often the case that the depilatory cream doesn’t manage to loosen every hair because hair thickness is never completely uniform. That’s OK: You can always pluck or shave any strays that get left behind.

Rinse thoroughly

Now is not the time to conserve water. Make sure you wash depilatory creams off completely to avoid a chemical burn.

Don’t forget aftercare

You’ve washed the product off. Now what?

“I would recommend using a moisturizer,” Scarso says. “Fragrance-free, nothing with perfumes … just a gentle, calming moisturizer to protect the skin.”


Who shouldn’t use depilatory creams?

As you can probably imagine, rubbing thioglycolic acid on your body isn’t going to be a good idea for all people.

“If you have any kind of compromised skin, you always need to be careful with what you’re putting on it,” Scarso notes.

That includes people with sensitive skin or medical conditions like rosacea, eczema, psoriasis … even sunburn or acne. It also includes people using skin products (like retinols or retinoids) that make their skin more sensitive.

Always do a patch test first

Even if you don’t have skin conditions, you may experience redness or irritation using a depilatory cream. That’s why you should always do a patch test first.

It’s also important to read up on the ingredients in any product you’re considering using, to ensure you aren’t allergic to any of the components.

The bottom line

Depilatory creams, used exactly as specified by the manufacturer, can be a wonderful DIY hair-removal option. They’re quick, affordable, painless and don’t require a trip to a spa or salon. But depilatory creams aren’t for everybody. And their side effects can be severe. People with sensitive or damaged skin should avoid these products, as should people with chronic skin conditions.

If you decide depilatory creams are a good option for you, it’s crucial to use the correct cream for the kind of hair you’re removing, conduct a patch test and rinse the cream off thoroughly within the time period specified on the packaging.

How and if you remove unwanted hair is a question of preference. The only way to know if depilatory cream’s your dream technique: Try it!

Learn more about our editorial process.

Related Articles

person holding smooth leg up
May 4, 2023/Skin Care & Beauty
Do Crystal Hair Erasers Actually Erase Hair?

They work for some skin types but are less efficient — and messier — than shaving

Person having eyebrow threading performed on their left eyebrow.
March 27, 2023/Skin Care & Beauty
String Theory: An Inside Look at Eyebrow Threading

This popular eyebrow-shaping technique is more precise than waxing — and often less painful!

Client in chair at hair salon with long smooth brown hair after a keratin hair treatment.
November 14, 2022/Skin Care & Beauty
What You Need To Know About Keratin Treatments

The popular salon service aims to give you smooth, shiny, frizz-free hair

sugaring hair removal
June 16, 2022/Skin Care & Beauty
What Is Sugaring? Pros and Cons of This Hair Removal Option

A paste of sugar, lemon and water can be gentler than traditional waxing

preparing for a brazilian wax
November 10, 2021/Skin Care & Beauty
What You Should Know About Getting a Brazilian Wax

Pros, cons and how to prep to go hair-free

woman shaving her legs
September 7, 2020/Skin Care & Beauty
Shaving vs. Waxing: What’s Better for Your Skin?

Two routes to smooth, hair-free skin

Fingers with globs of petroleum jelly above container
April 18, 2024/Skin Care & Beauty
Slugging: Does This Skin Care Trend Work?

Go ahead and get goopy to help boost hydration and repair damaged skin

Trending Topics

Person in yellow tshirt and blue jeans relaxing on green couch in living room reading texts on their phone.
Here’s How Many Calories You Naturally Burn in a Day

Your metabolism may torch 1,300 to 2,000 calories daily with no activity

woman snacking on raisins and nuts
52 Foods High In Iron

Pump up your iron intake with foods like tuna, tofu and turkey