Locations:
Search IconSearch

Is Your Newborn Baby’s Immune System Strong Enough?

How to protect your little one from bacteria and viruses

Seated mother holds small baby facing toward her as they smile at one another

You soothe your newborn baby’s cries, and you revel in their first smile. They need you for everything — and you want to protect them from everything — but how do you safeguard their still-developing immune system from sickness and flu?

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

“It’s important to consider, especially in the early weeks of a baby’s life,” says pediatrician Camille Sabella, MD.

“An infant’s immune system doesn’t mature until they’re about two to three months old,” Dr. Sabella says.

“In those first few months, the immune system — especially cell-mediated immunity — becomes more developed. This is very important in helping a child fight off viruses.”

This means that a 2-week-old baby’s immune system can’t fight viruses or bacteria nearly as well as a 3-month-old’s can.

On the bright side, the mother’s immune system does continue to protect her infant with antibodies that were shared through the placenta immediately after birth. “Those antibodies stay active for the first few weeks of a baby’s life,” Dr. Sabella says.

This offers some protection from bacteria and viruses. Breastfeeding also boosts this early immunity.

Know when to call a doctor about your baby’s sickness

There are plenty of ways to help cut down your baby’s risk of sickness.

For starters, know when you absolutely should call a doctor. This includes any of the following signs:

  • Difficult breathing.
  • Bluish skin or lip color.
  • Dehydration.
  • Fever.
  • Lethargy or failure to wake up.

Your baby’s vulnerability to viruses

Keep in mind that new babies are vulnerable to viruses. Here are some of the most common to watch out for:

Advertisement

  • Stomach virus. “Gastrointestinal viruses can present significant problems for infants,” Dr. Sabella says. They can cause dehydration resulting from diarrhea. These bugs also can quickly spread to the bloodstream if they strike during a baby’s first month of life. That kind of infection can cause liver damage, meningitis, encephalitis and heart inflammation.
  • Respiratory syncytial virus (RSV)Infants under six months of age who get this virus are often hospitalized. It can cause bronchiolitis, a condition where the small airways in the lungs swell block air flow and fill with mucus. RSV also causes pneumonia.
  • Flu. Infants get sicker with the flu than older children and adults do. “Although there is potential treatment of the flu virus, it often can turn into pneumonia or apnea,” Dr. Sabella says.

3 ways to reduce your baby’s risk of sickness

“There are things you can do to protect your baby during the first few months of life,” Dr. Sabella says.

1. Limit outside exposures

You can’t keep your baby in a bubble until they reach the six-month mark. But you can limit contact with other people. And ask visitors to wash their hands before touching the child.

“The first two months of life, we really regard as a sacred time to try to limit exposures as much as possible because babies can get viruses from people who don’t even know they’re contagious yet,” he says.

2. Watch for fever

In babies under 3 months, a rectal temperature of 100.4°F (38°C) or higher needs prompt medical evaluation. Depending on their age and exam findings, your clinician may recommend tests and sometimes antibiotics while results return.

3. Keep up with vaccines

Many pediatricians recommend starting routine infant vaccines at the 2-month visit to reduce the risk of serious infections. In particular, DTaP (protects against pertussis/whooping cough), Hib, and pneumococcal (PCV) help lower the risk of severe illness like meningitis and bloodstream infections in young infants.

If you’re expecting, ask your OB about Tdap during pregnancy (often in the third trimester), which can help protect your newborn from pertussis before they’re old enough for their own shots.

If you’re weighing timing or have questions, talk with your pediatrician about your baby’s health history and the plan that fits your family.

Bottom line

Stay aware, use common-sense precautions and reach out to your pediatrician when you’re unsure. That partnership goes a long way in the first months.

Advertisement

Learn more about our editorial process.

Related Articles

Gloved hands of healthcare provider giving a shot in the shoulder of a young child
November 15, 2024/Children's Health
Well-Check Schedule for Children

These kids’ visits include getting important vaccines and checking on developmental milestones

Baby in onesie asleep on back
February 12, 2024/Children's Health
When Can I Put My Baby To Sleep on Their Stomach?

Your baby needs to able to roll in both directions before they can make the switch

Mother bottle feeding her premature baby
February 25, 2020/Pregnancy & Childbirth
7 Things to Know About Bringing Your Baby Home From the NICU

Answers to common questions parents of preemies have

Children in a barn on a farm, standing and sitting on hay bales, petting an animal
June 13, 2025/Infectious Disease
Is the Hygiene Hypothesis True or False?

We don’t fully understand how cleanliness impacts immune system development, but we do know that preventing illness is important

Caregiver kissing smiling baby
May 6, 2025/Children's Health
When Do Babies Start Smiling and Laughing?

‘Social smiles’ typically start around 8 weeks old, while laughter comes later — around 4 to 6 months

Baby with pacifier sitting in stroller, being strapped in
April 18, 2025/Children's Health
What Is Container Baby Syndrome?

Too much time in certain infant ‘containers’ can cause developmental delays and a flat spot on baby’s head

Two men showing flu symptoms, as woman observes them suspiciously
What Is ‘Man Flu’?

You might feel like men exaggerate their symptoms when they’re sick — but research suggests the struggle might be real

Person sitting up in bed holding hot mug, with thermometer in mouth, with perspiration
What Happens When Your Body Has a Fever

When your body is fighting infection, your internal temperature rises as a defensive response

Trending Topics

Person in bed sleeping on their side, covers off
Breathing Problems? Try These Sleep Positions

If you’re feeling short of breath, sleep can be tough — propping yourself up or sleeping on your side may help

A couple looking at skyline, with one person slightly behind the other, head bent down
What Is Anxious Attachment Style — and Do You Have It?

If you fear the unknown or find yourself needing reassurance often, you may identify with this attachment style

Glasses and bottle of yellow-colored prebiotic soda, with mint, lemon and ginger garnish
Are Prebiotic Sodas Good for You?

If you’re looking to boost your gut health, it’s better to get fiber from whole foods

Ad