Locations:
Search IconSearch
July 19, 2023/Living Healthy/Wellness

Here’s What You Need To Know About L-Theanine

Timing and pairing are important to reap the possible benefits of this amino acid

A cup of frothy green tea in foreground and powdered matcha in background.

If you deal with daily stress or trouble sleeping, you’ve probably turned to a hot cup of tea to settle your nerves. Indeed, there’s good reason tea has a reputation for being so comforting. Research shows that tea can help with everything from lowering cholesterol to improving gut health.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

So, it’s natural to think about the ingredients in tea that make it so beneficial. Enter L-theanine — an amino acid that’s present in tea leaves. It’s also used as a supplement, as it may help with anxiety and sleep conditions.

Dietitian Julia Zumpano, RD, LD, talks about what l-theanine is and what you should know before you consider taking it.

What is L-theanine?

L-theanine is an amino acid found in tea leaves, particularly green tea and loose-leaf tea, that has several potential health benefits. But first, let’s go over what amino acids are and why they’re important.

“Amino acids are proteins and they’re really the building blocks of our life,” explains Zumpano. “Amino acids are molecules used by all living things to make proteins. In total, we as humans need 20 different amino acids to function properly. But there are those 11 essential amino acids that our body really needs to get through food.”

While L-theanine isn’t essential for our survival, its presence in plants and fungi has been studied for its possible impact on our brain function.

L-theanine can be taken by drinking certain teas like green teas, white teas or matcha. It can also be taken as a tablet or pill form.

Benefits of L-theanine

But if you’ve looked up the benefits of L-theanine, you may have started to scratch your head. Some proponents claim it can help you feel more alert, while others say that it can help with insomnia. So, which is it? As Zumpano points out, the best way to get the most use out of L-theanine has a lot to do with when you’re taking it and what you’re pairing it with.

Advertisement

It’s also important to know that these effects may vary from person to person and that there’s still limited research on the benefits of taking L-theanine to help with mental and cognitive issues.

Here are some of the explored benefits of L-theanine:

Improving sleep quality

You may have heard that taking L-theanine before bed can help if you experience disruptive sleep or have trouble falling asleep. A 2019 study explored the benefits of an L-theanine and GABA supplement combination on sleep quality and length. GABA, short for gamma-aminobutyric acid, is a naturally occurring chemical messenger in your brain that’s been linked to creating a calming effect. It’s also available as a dietary supplement. The study showed that this combination could potentially increase sleep duration and REM sleep.

According to Zumpano, if you’re looking to try L-theanine in tea or supplement form, it’s a good idea to take it in the evening before going to bed and not pair it with any coffee or caffeinated beverage. If you’re experiencing more serious sleep issues like insomnia or sleep apnea, L-theanine likely won’t do the trick.

Also, you should ask your healthcare provider before pairing any prescription medications with L-theanine before bed. L-theanine can be safely taken with melatonin, however.

Reducing stress and anxiety

Remember how a cup of tea can calm you down after a hectic day? Research shows that L-theanine supplements can elevate your levels of GABA, dopamine and serotonin, which promotes relaxation and reduces anxiety levels.

A randomized trial from 2019 found that healthy adults who took L-theanine over the course of four weeks had a decrease in stress-related symptoms. While these results are promising, it’s important to remember that stress reduction will look different for everyone, depending on what stress response you’re having and when you’re experiencing it.

Boosting mental clarity

If you’re feeling brain fog or a general blah feeling, L-theanine may be able to help give you a boost of mental clarity and enhance your ability to focus. According to the same 2019 study, L-theanine helped healthy adults with verbal fluency and the ability to stay focused. The benefits are heightened when taken with caffeine.

“If you’re going to take L-theanine to gain more alertness and mental clarity, you should take it during the day,” advises Zumpano. “It does seem to do better with coffee or a caffeinated beverage.”

Side effects and risks

L-theanine is generally considered safe and well-tolerated when taken at appropriate doses. In general, it’s recommended that you don’t exceed 500 milligrams (mg) a day. Most healthy adults can take between 200 mg and 500 mg a day.

Advertisement

But like any supplement, it may cause side effects, particularly at high doses. You can also simply try upping your tea intake to help get a good dose of L-theanine.

“If you’re trying to get your L-theanine in the form of black tea or green tea, then you’re going to have similar side effects like having too much caffeine,” notes Zumpano.

Some of the reported side effects of L-theanine include:

  • Headaches.
  • Dizziness.
  • Nausea.
  • Jitteriness.
  • Irritability.
  • Diarrhea.

Is it safe?

It’s important to add that these L-theanine side effects are relatively uncommon and tend to be mild. L-theanine is generally considered safe for most people, but it’s always a good idea to talk to your healthcare provider before taking any new supplement, especially if you have any underlying health conditions or are taking medications. In addition, pregnant or breastfeeding (chestfeeding) people should also exercise caution when taking L-theanine, as there’s limited research on its safety in these populations.

“As of right now, the FDA has classified L-theanine as generally safe, but we don’t have specific guidelines on how to take it, just what the studies have shown,” adds Zumpano.

It’s also important to know that, like all supplements, the U.S. Food and Drug Administration (FDA) doesn’t review or regulate L-theanine products. This means no one checks what’s sold to ensure it’s safe and effective. If you’re planning to try L-theanine in supplement form, you should look for a high-quality version with no added fillers.

Advertisement

Advertisement

Learn more about our editorial process.

Health Library
Amino Acids

Related Articles

Orange capsules poured out of a bottle
January 17, 2025/Heart Health
Taking a Statin? Here’s Why You Don’t Need CoQ10 Supplements

There’s not enough evidence to show that this supplement has any effect on muscle aches from cholesterol-lowering meds

Older person in green cardigan, with hearts around
January 14, 2025/Wellness
Here’s How To Love Your Body More As an Adult

Focusing on non-physical attributes, practicing body positivity or neutrality, and avoiding comparisons can help

Orange plate of bright green sea moss
January 6, 2025/Nutrition
8 Potential Health Benefits of Sea Moss

This spiny sea veggie may help your heart, gut, immune system and more

Tan tablets pouring from bottle into a hand
December 24, 2024/Sleep
Does Magnesium Help You Sleep Better?

Research is limited on whether the supplement can help you snooze, and there may be better options

Wooden spoonful of activated charcoal tablets and capsules, and small dish of loose activated charcoal
December 2, 2024/Digestive
Should You Take Activated Charcoal for a Stomach Bug (or Any Other Reason)?

Charcoal pills are used in certain emergency room settings but aren’t recommended for home use

Lavender shrubs
November 25, 2024/Wellness
6 Lavender Benefits and How To Use It

This purple perennial has many uses, including sleep hygiene, reducing inflammation and pain, and elevating mood

Child imagining being afraid of getting a shot, and then being afraid while actually getting a shot by a healthcare provider
November 19, 2024/Primary Care
What’s the Nocebo Effect? Examples and Effects on Your Health

The nocebo effect is a phenomenon where expectations of negative outcomes may influence the results

Sources of vitamin D, including foods like fish and dairy, sunshine and supplements
October 25, 2024/Nutrition
What Does Vitamin D Do?

The benefits of vitamin D include stronger bones, a hardier immune system and better overall health

Trending Topics

Person in bed sleeping on their side, covers off
Breathing Problems? Try These Sleep Positions

If you’re feeling short of breath, sleep can be tough — propping yourself up or sleeping on your side may help

A couple looking at skyline, with one person slightly behind the other, head bent down
What Is Anxious Attachment Style — and Do You Have It?

If you fear the unknown or find yourself needing reassurance often, you may identify with this attachment style

Glasses and bottle of yellow-colored prebiotic soda, with mint, lemon and ginger garnish
Are Prebiotic Sodas Good for You?

If you’re looking to boost your gut health, it’s better to get fiber from whole foods

Ad