Locations:
Search IconSearch

When Your Child’s ‘Chapped Cheeks’ May Actually Be a Common Childhood Infection

Understanding Fifth disease

Little girl with chapped cheeks - fifth disease

A rash has blossomed on your baby’s face. Of course, you’re concerned. You wonder if it hurts. Will it spread? What does it mean?

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Fifth disease, or erythema infectiosum, is a viral infection that can cause a rash on the face and body. It’s sometimes also called “slapped face syndrome.” It can also affect other parts of the body, including the upper arms, torso and legs, appearing as a more spread out red, lacy rash.

Pediatrician Kimberly Churbock, MD, says it’s common for babies and younger kids to bring home this infection from daycare or preschool ― and it’s usually not cause for alarm. Here, she explains what you need to know about fifth disease:

Q: How can I tell if my child might have Fifth’s disease?

A: Keep an eye out for mild aches, fatigue, cold-like symptoms and sometimes a low-grade fever, which go away days before the rash appears. The rash may itch, but most children with Fifth disease aren’t as uncomfortable as their parents may assume by the look of it!

Parents often mistaken Fifth disease for chapped cheeks or another common viral/bacterial culprit in rashes: measles, scarlet fever, rubella, Duke’s disease (now considered one and the same as scarlet fever) or roseola. (Fun fact: Fifth disease was so named because it was the fifth of these six rash-producing infections to be identified.)

Rashes related to eczema, poison ivy and hand-foot-mouth disease can also be confused with Fifth disease.

Advertisement

Your child’s pediatrician can usually diagnose Fifth disease by simply looking at the rash.

Q: How do children catch Fifth’s disease?

A: A virus called parvovirus B19 causes Fifth disease. It’s spread through saliva and mucus when little ones cough, sneeze, share drinking cups, put toys in their mouth or touch each other’s hands and faces.

Q: When is my child contagious?

A: Once the rash appears, they typically aren’t contagious anymore. (Of course, this makes it all the harder to manage spreading Fifth’s disease in a school or other group setting.)

In kids with healthy immune systems, the virus usually goes away on its own within two weeks.

Q: How do you soothe those cheeks?

A: Try using an oral or topical antihistamine to help relieve the itch and keep the rash from getting more angry-looking from your child’s scratching. If they have some fever or achiness, including headache, acetaminophen or ibuprofen will help them feel better.

Q: Is there any way to protect my child from Fifth’s disease?

A: Unlike measles and rubella, there’s no vaccination for Fifth disease yet. Keeping your child home during a known outbreak at daycare or school might keep your child from contracting it, but preventing it otherwise is difficult. Many kids are exposed to Fifth disease and other infections and develop immunity without ever having symptoms of the disease itself.

Q: Who should be especially careful around someone with Fifth disease?

A: While most people experience only mild symptoms, children or adults with compromised immune systems or blood disorders, or women who are pregnant, should take extra care to avoid being around someone with Fifth disease. And they should see their doctor if they believe they have been exposed.

Older children and adults with Fifth disease may experience more joint stiffness than younger children, but this goes away within weeks.

Advertisement

Learn more about our editorial process.

Related Articles

Mom, child and teacher talk one-on-one at school
August 20, 2025/Allergies
How To Create an Allergy Action Plan for Your Child

An allergist can help you make a plan that includes information about what to do in case of an allergic emergency

People meeting at fast food for a meal
How To Care for Your Child Living With Type 1 Diabetes

Lead with empathy, involve other caregivers, and teach them how insulin helps them live a long and healthy life

Caregiver and child eating pizza together
June 3, 2024/Children's Health
Lasting Impact: The Long-Term Effects of Childhood Obesity

Early weight gain can lead to health issues like heart disease, diabetes and cancer

child kneeling down, holding head, with a headache
March 19, 2024/Children's Health
How Serious Are Headaches in Children?

Severe and debilitating headaches can affect the quality of your child’s life

Parent helps child with their inhaler at home.
October 24, 2023/Lung
Treating Asthma in Children: How Parents Can Help

Asthma-proof your home, keep notes and (try to) be patient with long-term treatments

child shy at school
October 27, 2021/Children's Health
Is Your Child Just Shy — Or Is It Selective Mutism?

Talk to your pediatrician; early treatment is key

Could Your Child’s Stomach Pain Be Kidney Stones?
October 20, 2021/Children's Health
Could Your Child’s Stomach Pain Be Kidney Stones?

Why kidney stones in kids are on the rise (and what to watch for)

Mom with sick baby virtual appointment with doctor
July 21, 2021/Children's Health
Could Your Child’s Tummy Pain Be Pancreatitis?

How to know when a stomachache is something more serious

Trending Topics

Assorted foods high in vitamin D, like salmon, with a vitamin D supplements
3 Foods High in Vitamin D

The ‘sunshine vitamin’ is found naturally in some fish and is added to other foods

Child standing on desk, disrupting the class
Understanding AuDHD

Autism and ADHD often go hand in hand, giving rise to the term AuDHD

Hands with red polished nails holding a packet of contraceptive, birth control pills
Can Your Birth Control Double as Emergency Contraception?

The Yuzpe regimen is less effective than other forms of emergency contraceptives, and it’s associated with more side effects

Ad