July 15, 2020

Recipe: Lettuce-Wrapped, Stuffed Bison Burgers

Lose the bun and enjoy more veggies and greens

Burger and tomato wrapped in lettuce, sitting in a white bowl atop a crumpled brown bag

These spinach, mushroom and tomato stuffed burgers might sound fancy, but they are easy to make. And when you wrap them in lettuce, they give you a delicious, bunless burger option.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy


1 tablespoon extra virgin olive oil
½ cup red onion, diced
½ cup mushrooms, chopped
1 tablespoon balsamic vinegar
2 cups spinach
1 small tomato, diced (liquids drained) or 1 tablespoon tomato paste
1 tablespoon Dijon mustard
Sea salt and pepper, to taste
16 ounces ground bison (can substitute ground grass-fed beef or turkey)
8 outer leaves of romaine lettuce


  1. Heat oil over medium-high heat. Add onion, cook for 4 minutes. Reduce heat to medium. Stir in mushrooms.
  2. Add balsamic vinegar and stir. Cook for 5 minutes, stirring a few times.
  3. Add spinach and tomato and cook for another minute. Stir in mustard and turn off heat. Season with salt and pepper. Drain off excess liquid and reserve. Cool in refrigerator for 15 minutes.
  4. Form bison into 4 equally sized balls. With your fingers, make a well in the center of each ball. Stuff about 2 tablespoons of spinach mixture inside each ball. Seal the top and flatten to form a patty.
  5. Grill or broil your burgers:
    To grill: Heat your grill pan using a little oil. When hot, grill each patty for about 2-3 minutes on each side or when desired doneness is reached. Repeat, as needed, depending on pan size.
    To broil: Set oven broiler to “high.” Place patties on a foil–lined baking sheet on top oven rack. Broil for about 3 minutes, flip patties over, and broil for about another 2 to 3 minutes or until burgers reach desired doneness.
  6. Let the burgers rest for a couple of minutes.
  7. Take 2 romaine leaves and sandwich your burger between them.

Nutritional information

Each burger contains:

Calories 347
Fat 21g
Saturated fat 8g
Cholesterol 94mg
Fiber 5g
Protein 30g
Carbohydrate 9g
Sodium 160mg


From the book, Eat Fat, Get Thin, by Mark Hyman, MD

Related Articles

A close-up of a grilled turkey burger on a wheat bun with sliced tomato and leafy lettuce
May 25, 2022
Recipe: Grilled Turkey Burgers With Parsley and Dill

Time to fire up the grill!

Turkey burger with onions peppers and apples
July 27, 2020
Recipe: Turkey Burgers with Apples, Onions and Peppers

Prepare these lean burgers on the grill or in a skillet

turkey burger with sun dried tomatoes and avocado cream
July 2, 2020
Recipe: Turkey Burgers With Sun-Dried Tomato and Avocado Cream

Delicious and full of amazing flavor

pumpkin ravioli with mushroom sauce
February 22, 2024
Recipe: Pumpkin Ravioli With Wild Mushrooms

A satisfying and savory meal sure to impress family and friends

low-fat creamy Italian dip in bowl, with assorted veggies around
February 20, 2024
Recipe: Low-Fat Creamy Italian Dip

A low-sugar, low-fat dip perfect for snacking

Hot cinnamon baked acorn squash on parchment paper
February 15, 2024
Recipe: Baked Cinnamon Acorn Squash

Subtly sweet, buttery and vitamin-packed

Closeup of a lentil salad containing lentils, cauliflower, peppers, zucchini in a white bowl on a wooden table
February 13, 2024
Recipe: Herb-Friendly Lentil Salad

This delicious Mediterranean dish is packed with healthy protein and nutrients

variety of muffins in a basket
February 9, 2024
Recipe Adventure: Baking a Healthier Muffin

From classic pumpkin spice to trendy sweet potato quinoa, these eight recipes deliver delicious results in under 200 calories

Trending Topics

close up of keto gummies
Do Keto Gummies Work for Weight Loss? Are They Safe?

Research is inconclusive whether or not these supplements are helpful

Person in yellow tshirt and blue jeans relaxing on green couch in living room reading texts on their phone.
Here’s How Many Calories You Naturally Burn in a Day

Your metabolism may torch 1,300 to 2,000 calories daily with no activity

Older person postioned sideways showing dowager hump.
Dowager’s Hump: What It Is and How To Get Rid of It

The hump at the base of your neck may be caused by osteoporosis or poor posture